Aquaporin 4 and the endocannabinoid system: a potential therapeutic target in brain injury
Abstract Brain edema is a critical complication arising from stroke and traumatic brain injury (TBI) with an important impact on…
Review Article
DNA Methylation in Autism Spectrum Disorders: Biomarker or Pharmacological Target?
Abstract Autism spectrum disorder (ASD) is a group of heterogeneous neurodevelopmental disabilities with persistent impairments in cognition, communication, and social…
Natural Product-Inspired Dopamine Receptor Ligands
Abstract Due to their evolutionary bias as ligands for biologically relevant drug targets, natural products offer a unique opportunity as…
Cannabis therapy in rheumatological diseases: A systematic review
Abstract Cannabis has been used in rheumatic diseases as therapy for chronic pain or inflammatory conditions. Herein, the authors systematically…
The Effect of Phytocannabinoids and Endocannabinoids on Nrf2 Activity in the Central Nervous System and Periphery
Abstract The relationship between nuclear factor erythroid 2-related factor 2 (Nrf2) and phytocannabinoids/endocannabinoids (pCBs/eCBs) has been investigated in a variety…
The Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update
Abstract The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis has been used for several millennia…
Investigating endocannabinoid system and subjective responses to exercise in cancer patients: Rationale and future research directions
Abstract Over forty years of evidence supports the integration of exercise therapy in cancer care. However, most cancer patients remain…
Interactions of antidepressants with concomitant medications—safety of complex therapies in multimorbidities
Abstract Depression is the fourth most serious disease in the world. Left untreated, it is a cause of suicide attempts,…
Consensus panel recommendations for the optimization of EPIDIOLEX® treatment for seizures associated with Lennox–Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex
Abstract Plain language summary: Epidiolex® (cannabidiol) is approved for treating seizures in Lennox–Gastaut syndrome, Dravet syndrome, and tuberous sclerosis complex.…
Promoting diversity in clinical trials: insights from planning the ALUMNI AD study in historically underrepresented US populations with early symptomatic Alzheimer’s disease
Abstract Clinical trial participation across disease areas, including Alzheimer’s disease (AD), has been biased towards White participants of European ancestry.…