The grass isn’t always greener: The effects of cannabis on embryological development
Abstract With the increasing publicity of marijuana due to recent legislation, it is pertinent that the effects of fetal exposure…
Review Article
Endocannabinoid signaling in social functioning: an RDoC perspective
Abstract Core deficits in social functioning are associated with various neuropsychiatric and neurodevelopmental disorders, yet biomarker identification and the development…
Impact of Cannabis, Cannabinoids, and Endocannabinoids in the Lungs
Abstract Since the identification of cannabinoid receptors in the 1990s, a research field has been dedicated to exploring the role…
Current Therapeutic Cannabis Controversies and Clinical Trial Design Issues
Abstract This overview covers a wide range of cannabis topics, initially examining issues in dispensaries and self-administration, plus regulatory requirements…
Targeting Cannabinoid CB2 Receptors in the Central Nervous System. Medicinal Chemistry Approaches with Focus on Neurodegenerative Disorders
Abstract Endocannabinoids activate two types of specific G-protein-coupled receptors (GPCRs), namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions…
Cannabidiol, among Other Cannabinoid Drugs, Modulates Prepulse Inhibition of Startle in the SHR Animal Model: Implications for Schizophrenia Pharmacotherapy
Abstract Schizophrenia is a severe psychiatric disorder that involves positive, negative and cognitive symptoms. Prepulse inhibition of startle reflex (PPI)…
N-3 Polyunsaturated Fatty Acids through the Lifespan: Implication for Psychopathology
Abstract Objective: The impact of lifetime dietary habits and their role in physical, mental, and social well-being has been the…
Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents
Abstract The basic mechanism of the major neurodegenerative diseases, including neurogenic pain, needs to be agreed upon before rational treatments…
The Classification of Substance Use Disorders: Historical, Contextual, and Conceptual Considerations
Abstract This article provides an overview of the history of substance use and misuse and chronicles the long shared history…
A Belated Green Revolution for Cannabis: Virtual Genetic Resources to Fast-Track Cultivar Development
Abstract Cannabis is a predominantly diecious phenotypically diverse domesticated genus with few if any extant natural populations. International narcotics conventions…