Cannabinoids As Potential Treatment for Chemotherapy-Induced Nausea and Vomiting
Abstract Despite the advent of classic anti-emetics, chemotherapy-induced nausea is still problematic, with vomiting being somewhat better managed in the…
Review Article
Endocannabinoid system as a regulator of tumor cell malignancy – biological pathways and clinical significance
Abstract The endocannabinoid system (ECS) comprises cannabinoid receptors (CBs), endogenous cannabinoids, and enzymes responsible for their synthesis, transport, and degradation…
The CB2 receptor and its role as a regulator of inflammation
Abstract The CB2 receptor is the peripheral receptor for cannabinoids. It is mainly expressed in immune tissues, highlighting the possibility…
Sex Effects of Marijuana on Brain Structure and Function
Abstract Background: Tetrahydrocannabinol (Δ9-THC), the primary ingredient in marijuana, exerts its effects across several neurological and biological systems that interact…
Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
Abstract Medicine continues to struggle in its approaches to numerous common subjective pain syndromes that lack objective signs and remain…
Maintenance of Blinding in Clinical Trials and the Implications for Studying Analgesia Using Cannabinoids
Abstract The design of analgesic clinical trials invariably involves a comparison between placebo and active study medication. An assumption is…
Effect of Pharmacological Modulation of the Endocannabinoid System on Opiate Withdrawal: A Review of the Preclinical Animal Literature
Abstract Over the years, animal studies have revealed a role for the endocannabinoid system in the regulation of multiple aspects…
Marijuana, the Endocannabinoid System and the Female Reproductive System
Abstract Marijuana use among women is highly prevalent, but the societal conversation on marijuana rarely focuses on how marijuana affects…
Endocannabinoid control of glutamate NMDA receptors: the therapeutic potential and consequences of dysfunction
Abstract Glutamate is probably the most important excitatory neurotransmitter in the brain. The glutamate N-methyl-D-aspartate receptor (NMDAR) is a calcium-gated…
Can You Pass the Acid Test? Critical Review and Novel Therapeutic Perspectives of Δ9-Tetrahydrocannabinolic Acid A
Abstract Δ9-tetrahydrocannabinolic acid A (THCA-A) is the acidic precursor of Δ9-tetrahydrocannabinol (THC), the main psychoactive compound found in Cannabis sativa.…