Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor
Abstract Wnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of…
Research Article
Planning, implementation, evaluation, and sustainment of digital health interventions for adolescent substance use prevention: a systematic review of influencing factors based on the RE-AIM framework
Abstract School-based health interventions can help prevent adolescent substance use, but their success depends on various factors affecting planning and…
Risk factors of sexual and reproductive health problems, service utilization, and its challenges among street youths in East Gojjam zone, North West Ethiopia: exploratory qualitative study
Abstract Background: Children on the streets are still vulnerable to early and unsafe sexual experiences. Having multiple sexual partners and…
Multi-ancestry genetic architecture of sleep duration and its relationship to other sleep and psychiatric phenotypes
Abstract Differences in sleep duration, quality, and timing are associated with variation in cognition, health outcomes, and quality of life.…
Transcriptomic analysis of CDL-gated photoperiodic flowering mechanisms in cannabis and their responsiveness to R: FR ratios in controlled environment agriculture
Abstract While discrete regulatory mechanisms have been identified, a unified model for the transcriptional activation of photoperiodic flowering in short-day…
Green Propolis Extract‐Mediated Synthesis of Biogenic Silver Nanoparticles: In Vitro Antileishmanial and Antibacterial Activities, Cytotoxicity and Ex Vivo Irritation Testing
Abstract This study describes the green synthesis, characterization, and biological evaluation of silver nanoparticles (AgNPs) obtained from green propolis (AgNPs‐PRO).…
Trends and Practices in Bariatric Surgery in Egypt: Insights on Esophagogastroduodenoscopy (EGD) Utilization and Surgical Volumes
Abstract Background: Esophagogastroduodenoscopy (EGD) is crucial in bariatric surgery for detecting gastro-esophageal conditions and incidental pathologies, impacting surgical decisions and…
Pan-cancer gene signature analysis of macrophage polarization and compound prediction for reprogramming tumor-associated macrophages toward M1-like macrophages
Abstract Background: Resting tumor-associated macrophages (TAMs) are stimulated by the tumor microenvironment and can be primarily polarized into two subtypes:…
Analysis of a pan-cancer panel reveals the amino acid metabolism-related gene MTHFD1 as a potential prognostic and immunotherapeutic biomarker
Abstract Methylenetetrahydrofolate dehydrogenase 1 (MTHFD1) serves a role in amino acid metabolism and may influence tumor progression. However, to the…
The prognostic and immune significance of fibronectin type III domain-containing 1 gene in pan-cancer and its relationship with proliferation and migration of stomach adenocarcinoma
Abstract Background: Fibronectin type III domain containing 1 (FNDC1) exhibits emerging roles in tumorigenesis, yet its pan-cancer implications and mechanistic…