Cannabidiol Loaded Nanoemulsion with Improved Bioaccessibility and Anti-Inflammatory Activity
Abstract Oral delivery of cannabidiol (CBD) is challenging because of its poor water solubility and low bioavailability, which restrict its…
Research Article
Effects of Medical Cannabis Treatment for Autistic Children on Family Accommodation: An Open-Label Mixed-Methods Study
Abstract Highlights: What are the main findings? Implications Abstract: Background/Objectives: Parents of autistic children often face behavioral and participation challenges…
The Cannabinoid CB1 Receptor Inverse Agonist/Antagonist SR141716A Activates the Adenylate Cyclase/PKA Signaling Pathway Among Other Intracellular Emetic Signals to Evoke Vomiting in Least Shrews (Cryptotis parva)
Abstract Intracellular emetic signals involved in the cannabinoid CB1 receptor inverse agonist/antagonist SR141716A were investigated. SR141716A (20 mg/kg, i.p.)-evoked vomiting…
Differential Effects of Cannabinoid Receptor 2 Agonists on HIV Replication and Inflammatory Activation in Monocyte-Derived Macrophages and Induced Pluripotent Stem Cell-Derived Microglia
Abstract Graphical Abstract: Created in BioRender. Espinoza, C. (2025) https://BioRender.com/mxfla3i Supplementary Information: The online version contains supplementary material available at…
Metabolic Profile of Male Cannabis Users and Estimation of Candidate Biomarkers
Abstract Tetrahydrocannabinol (THC), the primary psychoactive compound of cannabis, is the most widely abused substance worldwide, with an annual prevalence…
Head nurses’ transformational leadership and nurses’ job engagement: the mediating role of horizontal violence among nurses
Abstract Background: Horizontal violence among nurses is relatively prevalent and may affect nurses’ level of job engagement. By integrating Affective…
Influence of Cannabidiol Use on Visual Function and Optical Quality: A Randomized Controlled Trial
Abstract Purpose: To study the influence of different concentrations of vaporized cannabidiol (CBD; 0%, 15%, and 30%) on visual function…
Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation Control
Abstract Alzheimer’s disease (AD) has traditionally been associated with amyloid-β plaques, but growing evidence underscores the role of neuroinflammation in…
Cannabinoid CB1 receptor in dopaminergic circuit from ventral tegmental area to nucleus accumbens links trait anxiety with reward learning
Abstract The endocannabinoid (eCB) system has risen as a critical modulator linking the environmental challenges to behavioral maladaptation, such as…
Relevance of a peripheral site of action outside the brain-blood barrier for the beneficial effects of CB2 receptor activation in experimental ALS in male mice
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12964-025-02418-2. Article type: Research Article Keywords: Amyotrophic lateral sclerosis,…