Relevance of a peripheral site of action outside the brain-blood barrier for the beneficial effects of CB2 receptor activation in experimental ALS in male mice

Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12964-025-02418-2. Article type: Research Article Keywords: Amyotrophic lateral sclerosis, SOD-1, TDP-43, Cannabinoids, Endocannabinoid system, CB, Neuroprotection, Neural compartments, Muscle compartments, Immune cells Authors: Marta Gómez-Almería, Claudia Gonzalo-Consuegra, Carmen Rodríguez-Cueto, María Cabañas-Cotillas, Alberto Jiménez-Amor, Isabel Machín-Díaz, Matthias B. Wittwer, Pawel Dzygiel, Diego Clemente, Uwe Grether, Javier Fernández-Ruiz ⚬, Eva de Lago ⚬ Affiliations: https://ror.org/02p0gd045grid.4795.f0000 0001 2157 7667Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Investigación en