Advances in Targeting Growth Factor Signalling in Neuroblastoma and Overcoming Drug Resistance
Abstract Neuroblastoma is an embryonal tumour that arises from the malignant transformation of neural crest cells and remains one of…
Tumor heterogeneity
PIS as a regulator of cellular heterogeneity, prognostic significance, and immune landscape in thyroid cancer
Abstract Single-cell RNA sequencing (scRNA-seq) was used to dissect the cellular composition and gene expression patterns of thyroid cancer (THCA),…
Predicting Prognosis and Immunotherapy Response in Multiple Cancers Based on the Association of PANoptosis-Related Genes with Tumor Heterogeneity
Abstract PANoptosis is a newly recognized inflammatory pathway for programmed cell death (PCD). It participates in regulating the internal environment,…
Evolution of intra-tumoral heterogeneity across different pathological stages in papillary thyroid carcinoma
Abstract Background: Intra-tumor heterogeneity (ITH) results from the continuous accumulation of mutations during disease progression, thus impacting patients’ clinical outcome.…
Disparity between Inter-Patient Molecular Heterogeneity and Repertoires of Target Drugs Used for Different Types of Cancer in Clinical Oncology
Abstract Inter-patient molecular heterogeneity is the major declared driver of an expanding variety of anticancer drugs and personalizing their prescriptions.…