Abstract Hexim proteins are key RNA-dependent regulators of eukaryotic transcription through 7SK-dependent sequestration and inactivation of the kinase P-TEFb (Cdk9–CyclinT1/2)…
Abstract A central process contributing to the phenotype of aging is cellular senescence. We recently identified the FOXO4 – p53…
Abstract Orderly development of neuroendocrine and nervous system of mammals requires INSM1, a key regulator for cell differentiation. Ectopic expression…
Abstract Abnormal trinucleotide repeat expansions alter protein conformation causing malfunction and contribute to a significant number of incurable human diseases.…
Abstract Dynein and kinesin motors mediate long-range intracellular transport, translocating towards microtubule minus and plus ends, respectively. Cargoes often undergo…
Abstract Molecular chaperones are essential cellular components that aid in protein folding and preventing the abnormal aggregation of disease-associated proteins.…
Abstract Biomolecular polyelectrolyte complexes can be formed between oppositely charged intrinsically disordered regions (IDRs) of proteins or between IDRs and…
Abstract The RNA-binding motif protein RBM5 belongs to a family of multi-domain RNA binding proteins that regulate alternative splicing of…
Abstract Multivalent ligands of ion channels have proven to be both very rare and highly valuable in yielding unique insights…
Abstract Specificity of RNA-binding proteins for target sequences varies considerably. Yet, it is not understood how certain few proteins achieve…