PYK2 senses calcium through a disordered dimerization and calmodulin-binding element
Abstract Multidomain kinases use many ways to integrate and process diverse stimuli. Here, we investigated the mechanism by which the…
Solution-state NMR
Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor
Abstract The intracellular domain (ICD) of Cys-loop receptors mediates diverse functions. To date, no structure of a full-length ICD is…
HACS1 signaling adaptor protein recognizes a motif in the paired immunoglobulin receptor B cytoplasmic domain
Abstract Hematopoietic adaptor containing SH3 and SAM domains-1 (HACS1) is a signaling protein with two juxtaposed protein–protein interaction domains and…
UvrD helicase–RNA polymerase interactions are governed by UvrD’s carboxy-terminal Tudor domain
Abstract All living organisms have to cope with the constant threat of genome damage by UV light and other toxic…
Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29
Abstract VARP and TBC1D5 are accessory/regulatory proteins of retromer-mediated retrograde trafficking from endosomes. Using an NMR/X-ray approach, we determined the…
Structural heterogeneity of α-synuclein fibrils amplified from patient brain extracts
Abstract Parkinson’s disease (PD) and Multiple System Atrophy (MSA) are clinically distinctive diseases that feature a common neuropathological hallmark of…
Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules
Abstract Designing highly specific modulators of protein-protein interactions (PPIs) is especially challenging in the context of multiple paralogs and conserved…