Bioinformatics analysis identifies AURKB as a prognostic biomarker across multiple human cancers
Abstract Background: Cancer is a major global health issue. Aurora kinase B (AURKB) is known to regulate cell division and…
Pan-cancer analysis
Enhancing cancer susceptibility to disulfidptosis by inducing cell cycle arrest and impairing DNA repair
Abstract Disulfidptosis—a regulated cell death caused by disulfide stress under glucose starvation and high SLC7A11—offers a potential cancer vulnerability, but…
Pan-cancer atlas analysis of FANCB and its potential mechanism in cholangiocarcinoma
Abstract Cholangiocarcinoma (CHOL) is a tumor with high malignancy and poor prognosis, and its morbidity and mortality have increased significantly…
A pan-cancer analysis to predict the prognosis and immunological role of copper death-related gene DLAT
Abstract As the 2nd-leading cause of death, cancer poses a serious danger to human life and health. The pathogenesis and…
Comprehensive Pan-Cancer Analysis of ZNF668 Reveals the Prognostic and Immunological Significance of ZNF668
Abstract Transcription factors from the Zinc Finger Protein (ZFP) family are extensively implicated in tumorigenesis, yet the roles of many…
MCRS1 is associated with immunosuppressive microenvironments in pan-cancer and promotes hepatocellular carcinoma malignant phenotypes
Abstract Background: Pan-cancer analyses focused on the immunological significance and therapeutic potential of microspherule protein 1 (MCRS1) remain unreported. This…
Systematic pan-cancer analysis reveals the prognostic and immunological roles of ectonucleoside triphosphate diphosphohydrolase 6
Abstract BACKGROUND: Ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6), a member of the ENTPD family, has been implicated in certain cancers, yet…
Pan-cancer analysis reveals ELFN1 as a novel prognostic biomarker and immunotherapeutic target associated with tumor microenvironment remodeling and promoting malignant phenotypes in colorectal cancer
Abstract Background: Extracellular leucine rich repeat and fibronectin type III domain containing 1 (ELFN1), a transmembrane protein implicated in tumorigenesis…
Integrated Pan-Cancer Analysis and Experimental Verification of the Roles of Retinoid-Binding Proteins in Breast Cancer
Abstract Many cancers disrupt how vitamin A-related proteins control cell growth and death. We studied these proteins, especially RBP4 and…
Pan-cancer analysis identifies LMBR1L as a prognostic and immunological biomarker with validation in colorectal cancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40001-025-03404-7. Article type: Research Article Keywords: LMBR1L expression, Tumor…