Intellectual disability

April 16, 2026

Real‐world effectiveness of highly purified cannabidiol in epilepsy associated with 15q11.2‐q13.1 duplication and deletion syndromes: A multicenter study

Abstract Plain Language Summary: Epilepsy secondary to 15q11.2‐q13.1 duplication or deletion syndromes (15q‐DDS) is often severe, making daily life difficult…

March 24, 2025

Expanding the therapeutic role of highly purified cannabidiol in monogenic epilepsies: A multicenter real‐world study

Abstract Objective: This real‐world, retrospective, multicenter study aims to investigate the effectiveness of highly purified cannabidiol (CBD) in a large…

March 18, 2025

Clinical profiling and medical management of Israeli individuals with Phelan McDermid syndrome

Abstract Background: Phelan–McDermid syndrome (PMS) is a neurodevelopmental disorder, caused by haploinsufficiency of the SHANK3 gene. In addition to global…

September 19, 2024

Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1 receptor expression and rescues bioenergetic and cognitive defects in a female mouse model of Rett syndrome

Abstract Background: Defective mitochondria and aberrant brain mitochondrial bioenergetics are consistent features in syndromic intellectual disability disorders, such as Rett…

January 4, 2024

Cannabidiol (Epidyolex®) for severe behavioral manifestations in patients with tuberous sclerosis complex, mucopolysaccharidosis type III and fragile X syndrome: protocol for a series of randomized, placebo-controlled N-of-1 trials

Abstract Background: Many rare genetic neurodevelopmental disorders (RGNDs) are characterized by intellectual disability (ID), severe cognitive and behavioral impairments, potentially…

November 8, 2023

The potential for medicinal cannabis to help manage challenging behaviour in people with intellectual disability: A perspective review

Abstract Background: Around 2% of the population have intellectual disabilities. Over one-third people with intellectual disabilities (PwID) present with ‘challenging…

March 8, 2020

Does cannabidiol reduce severe behavioural problems in children with intellectual disability? Study protocol for a pilot single-site phase I/II randomised placebo controlled trial

Abstract Introduction: Severe behavioural problems (SBPs) are a common contributor to morbidity and reduced quality of life in children with…

October 29, 2015

Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling

Abstract One of the unique features of prenatal alcohol exposure in humans is impaired cognitive and behavioral function resulting from…