Pan‐cancer analysis reveals sex‐specific signatures in the tumor microenvironment
Abstract The processes of cancer initiation, progression, and response to therapy are affected by the sex of cancer patients. Immunotherapy…
immune cells within the tumor microenvironment
Pan-cancer analyses of pyroptosis with functional implications for prognosis and immunotherapy in cancer
Abstract Background: Programmed cell death is an active and orderly form of cell death regulated by intracellular genes that plays…
Immunotherapeutic Value of MAP1LC3C and Its Candidate FDA-Approved Drugs Identified by Pan-Cancer Analysis, Virtual Screening and Sensitivity Analysis
Abstract Background: The autophagy pathway within the tumour microenvironment can be regulated to inhibit or promote tumour development. In the…
An Integrated Pan-Cancer Analysis of ADAMTS12 and Its Potential Implications in Pancreatic Adenocarcinoma
Abstract Background: A Disintegrin and Metallopeptidase with Thrombospondin Type 1 Motif 12 (ADAMTS12), a member of the ADAMTS family of…
TSH-TSHR axis promotes tumor immune evasion
Abstract Background: Hormones are identified as key biological variables in tumor immunity. However, previous researches mainly focused on the immune…
The oncogenic role of treacle ribosome biogenesis factor 1 (TCOF1) in human tumors: a pan-cancer analysis
Abstract Treacle ribosome biogenesis factor 1 (TCOF1) plays a crucial role in multiple processes, including ribosome biogenesis, DNA damage response…
Secreted phosphoprotein 1 as a potential prognostic and immunotherapy biomarker in multiple human cancers
Abstract Secreted phosphoprotein 1 (SPP1) is involved in immune regulation, cell survival, and tumor progression. Studies have demonstrated that SPP1…
Systematic pan-cancer landscape identifies CARM1 as a potential prognostic and immunological biomarker
Abstract Background: Belonging to the protein arginine methyltransferase (PRMT) family, the enzyme encoded by coactivator associated arginine methyltransferase 1 (CARM1)…
Toward Tumor Fight and Tumor Microenvironment Remodeling: PBA Induces Cell Cycle Arrest and Reduces Tumor Hybrid Cells’ Pluripotency in Bladder Cancer
Abstract Simple Summary: Bladder cancer (BC) is the second most frequent cancer of the genitourinary system. More than 500,000 patients…
A Pan-Cancer Analysis of Tumor-Infiltrating B Cell Repertoires
Abstract Tumor-infiltrating B cells can play an important role in anti-tumor responses but their presence is not well understood. In…