Obtaining spatially resolved tumor purity maps using deep multiple instance learning in a pan-cancer study
Abstract Tumor purity is the percentage of cancer cells within a tissue section. Pathologists estimate tumor purity to select samples…
immune cells within the tumor microenvironment
Pan-Cancer Analysis of the Associations of TGFBI Expression With Prognosis and Immune Characteristics
Abstract Transforming growth factor-beta-induced (TGFBI) protein has important roles in tumor growth, metastasis, and immunity. However, there is currently no…
An Integrative Pan-Cancer Analysis of the Prognostic and Immunological Role of Casein Kinase 2 Alpha Protein 1 (CSNK2A1) in Human Cancers: A Study Based on Bioinformatics and Immunohistochemical Analysis
Abstract Background: Although emerging animal- or cell-based evidence supports the relationship between casein kinase 2 alpha protein 1 (CSNK2A1) and…
A Pan-Cancer Analysis of Cystatin E/M Reveals Its Dual Functional Effects and Positive Regulation of Epithelial Cell in Human Tumors
Abstract Cystatin E/M (CST6), a representative cysteine protease inhibitor, plays both tumor-promoting and tumor-suppressing functions and is pursued as an…
A pan-cancer study of PD-1 and CTLA-4 as therapeutic targets
Abstract Background: Immunotherapy is a new and powerful weapon against tumors, represented by inhibitors of programmed death-1 (PD-1) and cytotoxic…
The Identification of Zinc-Finger Protein 433 as a Possible Prognostic Biomarker for Clear-Cell Renal Cell Carcinoma
Abstract Clear-cell renal cell carcinoma (ccRCC) is the most common and aggressive form of all urological cancers, with poor prognosis…
Prognostic and immunological role of Ras-related protein Rap1b in pan-cancer
Abstract Ras-related Protein Rap1b, a GTP-binding protein belonging to the proximal RAS, which affects tumor progression through regulating tumor cell…
Comprehensive analysis of DOK family genes expression, immune characteristics, and drug sensitivity in human tumors
Keywords: DOK, Tumor microenvironment, Immune infiltration, Drug sensitivity Authors: Yongjun Guan, Man Li, Zhendong Qiu, Junhui Xu, Yichao Zhang, Ning…
The Interplay between the Immune and the Endocannabinoid Systems in Cancer
Abstract The therapeutic potential of Cannabis sativa has been recognized since ancient times. Phytocannabinoids, endocannabinoids and synthetic cannabinoids activate two…
YTHDF1 Is a Potential Pan-Cancer Biomarker for Prognosis and Immunotherapy
Abstract Background: YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) has been indicated proven to participate in the cross-presentation of tumor…