Abstract The microtubule-associated protein tau is an intrinsically disordered protein containing a few short and transient secondary structures. Tau physiologically…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-023-01655-1. Article type: Research Article Keywords: Astrocytes, Stem cells,…
Abstract Astrocytic tau aggregates are seen in several primary and secondary tauopathies, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD),…
Abstract Graphical Abstract: Article type: Review Article Keywords: Alzheimer’s disease, Sleep, Proteostasis, Autophagy, Unfolded protein response, Tau, β-amyloid Authors: Christopher…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-022-01485-7. Article type: Research Article Keywords: Dentate gyrus, Frontotemporal…
Abstract Highlights: Abstract: Neurodegenerative parkinsonian disorders are characterized by a great diversity of clinical symptoms and underlying neuropathology, yet differential…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00401-022-02483-8. Article type: Research Article Keywords: Progressive supranuclear palsy,…
Abstract The detection and staging of Alzheimer’s disease (AD) using non-invasive imaging biomarkers is of substantial clinical importance. Positron emission…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-021-01271-x. Article type: Research Article Keywords: Tauopathy, Machine learning,…
Abstract Several common and debilitating neurodegenerative disorders are characterized by the intracellular accumulation of neurofibrillary tangles (NFTs), which are composed…