In vivo coupling of dendritic complexity with presynaptic density in primary tauopathies
Abstract Dendritic complexity and presynaptic density are reduced in the 4R-tauopathies of PSP and CBD. The reduction in ODI and…
Genetic tauopathy
Human tauopathy-derived tau strains determine the substrates recruited for templated amplification
Abstract Tauopathies are a subset of neurodegenerative diseases characterized by abnormal tau inclusions. Specifically, three-repeat tau and four-repeat tau in…
Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice
Abstract The aggregation of abnormally phosphorylated tau protein in neurons and glia is a neuropathological hallmark of several neurodegenerative disorders,…
In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00401-020-02253-4. Article type: Research Article Keywords: tauopathy, tau spreading,…
Contribution of the astrocytic tau pathology to synapse loss in progressive supranuclear palsy and corticobasal degeneration
Abstract Primary 4‐repeat tauopathies with frontotemporal lobar degeneration (FTLD) like Progressive Supranuclear Palsy (PSP) or Corticobasal Degeneration (CBD) show diverse…
Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy
Abstract Tauopathies are a class of neurodegenerative diseases, including Alzheimer’s disease (AD), Frontotemporal Dementia (FTD), Progressive Supranuclear Palsy (PSP), Corticobasal…
Associations of mitochondrial genomic variation with corticobasal degeneration, progressive supranuclear palsy, and neuropathological tau measures
Abstract Electronic supplementary material: The online version of this article (10.1186/s40478-020-01035-z) contains supplementary material, which is available to authorized users.…
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies
Abstract Primary tauopathies are characterized neuropathologically by inclusions containing abnormal forms of the microtubule-associated protein tau (MAPT) and clinically by…
Tau exhibits unique seeding properties in globular glial tauopathy
Abstract Electronic supplementary material: The online version of this article (10.1186/s40478-019-0691-9) contains supplementary material, which is available to authorized users.…
Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)
Abstract Pathological tau aggregates in Alzheimer’s disease (AD) and frontotemporal lobar degeneration-tau (FTLD-tau) adopt distinct conformations differentiated by the AD-tau…