Endocannabinoid levels in female-sexed individuals with diagnosed depression: a systematic review
Abstract Background: Major depressive disorder (MDD) is a highly prevalent mental health disorder with females experiencing higher rates of depression…
endocannabinoid system
Exploring the versatile roles of the endocannabinoid system and phytocannabinoids in modulating bacterial infections
Abstract The endocannabinoid system (ECS), initially identified for its role in maintaining homeostasis, particularly in regulating brain function, has evolved…
Inflammation and cancer: friend or foe?
Abstract Chronic inflammation plays a crucial role in the onset and progression of pathologies like neurodegenerative and cardiovascular diseases, diabetes,…
Modulation of Oxidative Stress and Neuroinflammation by Cannabidiol (CBD): Promising Targets for the Treatment of Alzheimer’s Disease
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease and the most common form of dementia globally. Although the direct…
Cannabinoids and healthy ageing: the potential for extending healthspan and lifespan in preclinical models with an emphasis on Caenorhabditis elegans
Abstract There is a significant global upsurge in the number and proportion of older persons in the population. With this…
A review of the direct targets of the cannabinoids cannabidiol, Δ9-tetrahydrocannabinol, N-arachidonoylethanolamine and 2-arachidonoylglycerol
Abstract Marijuana has been used by humans for thousands of years for both medicinal and recreational purposes. This included the…
Heteromers Formed by GPR55 and Either Cannabinoid CB1 or CB2 Receptors Are Upregulated in the Prefrontal Cortex of Multiple Sclerosis Patients
Abstract Multiple sclerosis (MS) is an autoimmune, inflammatory, and neurodegenerative disease of the central nervous system for which there is…
Potential Therapeutic Targets to Modulate the Endocannabinoid System in Alzheimer’s Disease
Abstract Alzheimer’s disease (AD), the most common neurodegenerative disease (NDD), is characterized by chronic neuronal cell death through progressive loss…
Linking the Autotaxin-LPA Axis to Medicinal Cannabis and the Endocannabinoid System
Abstract Over the past few decades, many current uses for cannabinoids have been described, ranging from controlling epilepsy to neuropathic…
Sex Differences in the Acute Effects of Oral THC: A Randomized, Placebo-Controlled, Crossover Human Laboratory Study
Abstract Rationale: Recent reports have shown increased cannabis use among women, leading to growing concerns about cannabis use disorder (CUD).…