Huntingtin CAG repeats in neuropathologically confirmed tauopathies: Novel insights
Abstract Previous studies have suggested a relationship between the number of CAG triplet repeats in the HTT gene and neurodegenerative…
corticobasal degeneration
Age-Related Pathology in Corticobasal Degeneration
Abstract Elderly human brains are vulnerable to multiple proteinopathies, although each protein has a different transmission pathway. Tau-immunoreactive astrocytes are…
Determinants of astrocytic pathology in stem cell models of primary tauopathies
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-023-01655-1. Article type: Research Article Keywords: Astrocytes, Stem cells,…
Diagnostic accuracy of cerebral [18F]FDG PET in atypical parkinsonism
Abstract Background: Atypical parkinsonism (AP) often presents with Parkinson’s symptoms but has a much worse long-term prognosis. The diagnosis is…
Determinants of Astrocytic Pathology in Stem Cell Models of Primary Tauopathies
Abstract Astrocytic tau aggregates are seen in several primary and secondary tauopathies, including progressive supranuclear palsy (PSP), corticobasal degeneration (CBD),…
Neurological update: non-motor symptoms in atypical parkinsonian syndromes
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00415-023-11807-x. Article type: Research Article Keywords: Parkinson’s disease, Atypical…
Case report of a patient with unclassified tauopathy with molecular and neuropathological features of both progressive supranuclear palsy and corticobasal degeneration
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s40478-023-01584-z. Article type: Case Report Keywords: Progressive supranuclear palsy,…
The evolution of diagnosis from symptom onset to death in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) compared to Parkinson’s disease (PD)
Abstract Background: Misdiagnosis and delayed diagnosis in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are common. Few studies have…
Single-nucleus chromatin accessibility profiling highlights distinct astrocyte signatures in progressive supranuclear palsy and corticobasal degeneration
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00401-022-02483-8. Article type: Research Article Keywords: Progressive supranuclear palsy,…
Imaging pathological tau in atypical parkinsonisms: A review
Abstract [18F]AV-1451 displays mixed results for specificity to 4R CBD- and PSP-tau. [18F]PI-2620 and [18F]PM-PBB3 are the most promising second-generation…