Comprehensive analysis on the implications of IAH1 in cancer development and progression
Abstract Objective: This study aimed to elucidate the role of the IAH1 gene across multiple cancer types. Methods: Using multi-omics…
Cancer prognosis
Comprehensive analysis of zinc finger protein 367 as a potential pan-cancer diagnostic and prognostic biomarker and underlying biological mechanisms
Abstract Objective: Zinc finger protein 367 (ZNF367) acts as a transcription factor and has been identified as overexpressed in numerous…
Glucokinase Regulatory Protein (GCKR) Links Metabolic Reprogramming With Immune Exclusion: Insights From a Pan-Cancer Analysis and Gastric Cancer Validation
Abstract Glucokinase regulatory protein (GCKR) is a metabolic regulator implicated in glucose homeostasis, but its genetic and functional roles in…
Unveiling the significance of ADAM12 through pan-cancer analysis and experimental verification in gastric cancer
Abstract Background: ADAM12, a member of the disintegrin and metalloproteinase family, has been involved in multiple cancers, yet its precise…
The SNHG3/miR-148a-3p axis-mediated high expression of DNMT1 is correlated with poor prognosis and tumor immune infiltration in hepatocellular carcinoma
Abstract Background: Epigenetic reprogramming, particularly DNA methylation mediated by DNA-methyltransferase 1 (DNMT1), plays a crucial role in the pathogenesis of…
The multidimensional role of SLC16A4 in hepatocellular carcinoma in silico analysis: prognostic significance, metabolic pathways, and immune microenvironment regulation
Abstract Background: This study aims to analyze the expression patterns, clinical relevance, and biological functions of SLC16A4 across multiple cancer…
Expressions, immune associations, and prognostic values of mitochondrial ribosomal protein MRPL3 in the pan cancer landscape
Abstract Background: MRPL3, a member of the mitochondrial ribosomal family, is involved in the translation of mitochondria-related proteins. However, its…
MFSD12 promotes proliferation, metastasis and invasion of hepatocellular carcinoma cells and its potential correlation with HAVCR2/LGALS9 immune checkpoint axis
Abstract Background: Major Facilitator Superfamily Domain-containing 12 (MFSD12) has emerged as a critical transmembrane protein with increasingly recognized roles in…
Pan-cancer analysis of INHBA indicates its potential prognostic value and correlation with HNSC and LIHC
Abstract Background: INHBA is a member of the TGF-β superfamily and is overexpressed in a variety of cancers and affects…
Comprehensive pan-cancer analysis of KRT6A as a prognostic and immune biomarker
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-19599-y. Article type: Research Article Keywords: KRT6A, Pan-cancer, Prognosis,…