CLIC6’s role in cancer: from broad analysis to breast cancer validation
Abstract Background: Chloride Intracellular Channel 6 (CLIC6) is a potential cancer therapy target due to its close association with tumor…
Cancer prognosis
Pan-cancer analysis of HOMER1 in hepatocellular carcinoma revealing diagnostic potential and immune landscape with experimental validation
Abstract Objective: Homer scaffold protein 1 (HOMER1), a postsynaptic scaffold protein, regulates excitatory synapses and intracellular signaling and has been…
DEP domain containing 1: a potential oncogenic driver
Abstract Background: DEP domain-containing protein 1 (DEPDC1) is essential for cell cycle regulation and is increasingly associated with multiple cancers.…
CORO1A: a pan-cancer prognosis, diagnostic and immune biomarker based on breast cancer validation
Abstract Introduction: CORO1A, a constituent of the Coronins family, is a conserved protein throughout evolution that interacts with actin within…
TPD52 promotes the proliferation and metastasis of gastric cancer cells
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12876-025-04295-y. Article type: Research Article Keywords: TPD52, Gastric cancer,…
CHMP4A in hepatocellular carcinoma: exploring its role in tumor progression, immune modulation, and potential link to TIM3 checkpoint
Abstract Background: Charged Multivesicular Body Protein 4A (CHMP4A), a member of the ESCRT-III family, plays a pivotal role in membrane…
Effect of immune-related intratumoral microbiota and host gene expression on cancer prognosis
Abstract IMPORTANCE: The intratumoral microbiota is a vital part of the tumor microenvironment, yet its interplay with host gene expression…
Comprehensive multi-omics analysis of CD36 in pan-cancers: Evaluating role in prognosis, immune microenvironment, and therapeutic response
Abstract Cluster of differentiation-36 (CD36) is involved in cellular adhesion, lipid metabolism, immunity, and inflammation. Multiple studies have enlightened the…
SMPD2 affects the prognosis of cancer patients by mediating lipid metabolism and the immune microenvironment
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12672-025-03553-5. Article type: Research Article Keywords: SMPD2, Biomarker, Immune…
A Six-Gene Mitochondrial Signature Predicts Prognosis in Dedifferentiated Thyroid Cancer
Abstract Background: Dedifferentiated thyroid cancer (DDTC) is a highly malignant, infiltrative neoplasm. Studies confirm mitochondrial (MD) dysfunction links to DDTC’s…