Cuproptosis: molecular mechanisms, cancer prognosis, and therapeutic applications
Abstract Cuproptosis differs from other forms of cell death, such as apoptosis, necroptosis, and ferroptosis, in its unique molecular mechanisms…
cancer immunotherapy
Metabolic regulation of myeloid-derived suppressor cells in tumor immune microenvironment: targets and therapeutic strategies
Abstract Cancer remains a major challenge to global public health, with rising incidence and high mortality rates. The tumor microenvironment…
Cuproptosis: a promising new target for breast cancer therapy
Abstract Breast cancer (BC) is the leading cause of cancer-related mortality among women globally, affecting approximately one-quarter of all female…
Cannabis Use Among Cancer Patients During Active Treatment: Findings From a Study at an NCI‐Designated Cancer Center
Abstract Objective: This study aims to describe patterns, sources, and reasons for cannabis use among cancer patients during active treatment…
Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy
Abstract Copper is an important trace element for maintaining key biological functions such as cellular respiration, nerve conduction, and antioxidant…
Prognostic value of TMTC1 in pan-cancer analysis
Abstract Background: Transmembrane and tetratricopeptide repeat containing 1 (TMTC1) is a recently discovered enzyme involved in the O-mannosylation of cadherins…
CD28 hinge used in chimeric antigen receptor (CAR) T-cells exhibits local structure and conformational exchange amidst global disorder
Abstract T-cell therapies based on chimeric antigen receptor (CAR) targeting of a tumor-specific antigen offer hope for patients with relapsed…
Cannabinoids and triple-negative breast cancer treatment
Abstract Triple-negative breast cancer (TNBC) accounts for about 10-20% of all breast cancer cases and is associated with an unfavorable…
Causal role of immune cells in thyroid cancer: a bidirectional Mendelian randomization study
Abstract Background: The immune system plays an important role in the development and treatment of thyroid cancer(THCA).However, the correlation between…
Small Molecule Therapeutics in the Pipeline Targeting for Triple-Negative Breast Cancer: Origin, Challenges, Opportunities, and Mechanisms of Action
Abstract Triple-negative breast cancer (TNBC) cells are devoid of estrogen receptors (ERs), progesterone receptor (PRs), and human epidermal growth factor…