Cancer biotherapy: review and prospect
Abstract Malignant tumors pose a grave threat to the quality of human life. The prevalence of malignant tumors in China…
cancer immunotherapy
Stem cell index-based RiskScore model for predicting prognosis in thyroid cancer and experimental verification
Abstract Objective: An mRNA expression-based stemness index (mRNAsi) has been developed to characterize cancer stemness. However, the predictive value of…
Predictive and Prognostic Relevance of Tumor-Infiltrating Immune Cells: Tailoring Personalized Treatments against Different Cancer Types
Abstract Simple Summary: This review summarizes the pivotal role of tumor-infiltrating immune cells (TIICs) within the tumor microenvironment (TME) and…
Novel T cell exhaustion gene signature to predict prognosis and immunotherapy response in thyroid carcinoma from integrated RNA-sequencing analysis
Abstract Exhausted CD8+ T lymphocytes and tumor-associated macrophages play critical roles in determining cancer prognosis and the efficacy of immunotherapy.…
Discovering single cannabidiol or synergistic antitumor effects of cannabidiol and cytokine-induced killer cells on non-small cell lung cancer cells
Abstract Introduction: A multitude of findings from cell cultures and animal studies are available to support the anti-cancer properties of…
An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2
Abstract The clinical utility of human interleukin-2 (hIL-2) is limited by its short serum half-life, preferential activation of regulatory T…
Current and future perspectives on the regulation and functions of miR-545 in cancer development
Abstract Micro ribonucleic acids (miRNAs) are a highly conserved class of single-stranded non-coding RNAs. Within the miR-545/374a cluster, miR-545 resides…
Targeting collagen in tumor extracellular matrix as a novel targeted strategy in cancer immunotherapy
Abstract Collagen, the most abundant protein in mammal, is widely expressed in tissues and organs, as well as tumor extracellular…
CCL5 might be a prognostic biomarker and associated with immuno-therapeutic efficacy in cancers: A pan-cancer analysis
Abstract Purpose: Chemokine ligand 5 (CCL5), a vital member of the CC chemokine family, plays diverse roles in tumorigenesis, metastasis,…
Human leukocyte antigen and tumor immunotherapy (Review)
Abstract Malignant tumors seriously endanger human health and life, and restrict economic development. Human leukocyte antigen (HLA) is the expression…