Most large structural variants in cancer genomes can be detected without long reads
Abstract Short-read sequencing is the workhorse of cancer genomics yet is thought to miss many structural variants (SVs), particularly large…
Cancer genomics
PFKP is a prospective prognostic, diagnostic, immunological and drug sensitivity predictor across pan-cancer
Abstract Phosphofructokinase, platelet (PFKP) is a rate-limiting enzyme of glycolysis that plays a decisive role in various human physio-pathological processes.…
Characterizing intergenic transcription at RNA polymerase II binding sites in normal and cancer tissues
Abstract Intergenic transcription in normal and cancerous tissues is pervasive but incompletely understood. To investigate this, we constructed an atlas…
Integrated multi-omics analysis reveals the molecular interplay between circadian clocks and cancer pathogenesis
Abstract Circadian rhythms (CRs) are fundamental biological processes that significantly impact human well-being. Disruption of these rhythms can trigger insufficient…
Molecular Mechanisms Underlying Potential Pathogen Resistance in Cannabis sativa
Abstract Cannabis (Cannabis sativa L.) is one of the earliest cultivated crops, valued for producing a broad spectrum of compounds…
Pan-cancer analysis of whole-genome doubling and its association with patient prognosis
Abstract Background: Whole-genome doubling (WGD) is a common mutation in cancer. Various studies have suggested that WGD is associated with…
Cancer genomes tolerate deleterious coding mutations through somatic copy number amplifications of wild-type regions
Abstract Cancers evolve under the accumulation of thousands of somatic mutations and chromosomal aberrations. While most coding mutations are deleterious,…
Pan-cancer genomic analysis shows hemizygous PTEN loss tumors are associated with immune evasion and poor outcome
Abstract In tumors, somatic mutations of the PTEN suppressor gene are associated with advanced disease, chemotherapy resistance, and poor survival.…
Systematic assessment of prognostic molecular features across cancers
Abstract Precision oncology promises accurate prediction of disease trajectories by utilizing molecular features of tumors. We present a systematic analysis…
Genomic disparities between cancers in adolescent and young adults and in older adults
Abstract Cancers cause significant mortality and morbidity in adolescents and young adults (AYAs), but their biological underpinnings are incompletely understood.…