Evaluating cancer etiology and risk with a mathematical model of tumor evolution
Abstract Recent evidence arising from DNA sequencing of healthy human tissues has clearly indicated that our organs accumulate a relevant…
Cancer genomics
RAS oncogenic activity predicts response to chemotherapy and outcome in lung adenocarcinoma
Abstract Activating mutations in KRAS occur in 32% of lung adenocarcinomas (LUAD). Despite leading to aggressive disease and resistance to…
The impact of rare germline variants on human somatic mutation processes
Abstract Somatic mutations are an inevitable component of ageing and the most important cause of cancer. The rates and types…
Cannabinoid Hyperemesis Syndrome Survey and Genomic Investigation
Abstract Background: Cannabinoid hyperemesis syndrome (CHS) is a diagnosis of exclusion with intractable nausea, cyclic vomiting, abdominal pain, and hot…
Pan‐cancer analysis of mutations in open chromatin regions and their possible association with cancer pathogenesis
Abstract Background: Open chromatin is associated with gene transcription. Previous studies have shown that the density of mutations in open…
Dissection of molecular and histological subtypes of papillary thyroid cancer using alternative splicing profiles
Abstract Despite growing evidence of the relevance of alternative splicing (AS) to cancer development and progression, the biological implications of…
Genetic fusions favor tumorigenesis through degron loss in oncogenes
Abstract Chromosomal rearrangements can generate genetic fusions composed of two distinct gene sequences, many of which have been implicated in…
Charting differentially methylated regions in cancer with Rocker-meth
Abstract Differentially DNA methylated regions (DMRs) inform on the role of epigenetic changes in cancer. We present Rocker-meth, a new…
Cannabis labelling is associated with genetic variation in terpene synthase genes
Abstract Analysis of over 100 Cannabis samples quantified for terpene and cannabinoid content and genotyped for over 100,000 single nucleotide…
A molecular taxonomy of tumors independent of tissue-of-origin
Abstract Cancer is an organism-level disease, impacting processes from cellular metabolism and the microenvironment to systemic immune response. Nevertheless, efforts…