Methamphetamine Use in People Living with HIV: Clinical, Neurocognitive, and Blood Biomarker Profiles
Abstract Background: Methamphetamine (MA) use in people living with HIV (PLWH) has been linked to neurocognitive and behavioral dysregulation. We…
biomarkers
EIF3M as a pan-cancer biomarker: prognostic significance and immune infiltration association
Abstract Background: EIF3M, a core subunit of eukaryotic translation initiation factor 3, plays a pivotal role in protein synthesis by…
Overexpressed MET drives aggressive thyroid cancer phenotypes and serves as a precision therapeutic target
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-23587-7. Article type: Research Article Keywords: MET, Thyroid cancer,…
MFSD12 promotes proliferation, metastasis and invasion of hepatocellular carcinoma cells and its potential correlation with HAVCR2/LGALS9 immune checkpoint axis
Abstract Background: Major Facilitator Superfamily Domain-containing 12 (MFSD12) has emerged as a critical transmembrane protein with increasingly recognized roles in…
Comprehensive pan-cancer analysis of KRT6A as a prognostic and immune biomarker
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-19599-y. Article type: Research Article Keywords: KRT6A, Pan-cancer, Prognosis,…
Pan-cancer analysis of HOMER1 in hepatocellular carcinoma revealing diagnostic potential and immune landscape with experimental validation
Abstract Objective: Homer scaffold protein 1 (HOMER1), a postsynaptic scaffold protein, regulates excitatory synapses and intracellular signaling and has been…
In Search of Molecular Correlates of Fibromyalgia: The Quest for Objective Diagnosis and Effective Treatments
Abstract Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain, fatigue, non-restorative sleep, and cognitive impairment. Its pathogenesis reflects…
FBXL22, a circadian-regulated immune biomarker with pan-cancer prognostic value and therapeutic potential in prostate cancer
Abstract F-box and leucine-rich repeat protein 22 (FBXL22) has been implicated in breast and prostate cancer types; however, comprehensive pan-cancer…
Comprehensive bioinformatics analysis reveals prognostic significance and immunological roles of WNT gene family in breast cancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-13315-6. Article type: Research Article Keywords: WNTs, Breast cancer,…
Pan-cancer evaluation of ABAT as an emerging biomarker and its implication in lung adenocarcinoma
Abstract Background: 4-aminobutyric acid aminotransferase (ABAT) is a pivotal enzyme for mitochondrial metabolism and central nervous system homeostasis, with known…