Fecal Metabolomics for the Diagnosis of Clostridioides difficile Infection
Abstract Background: Clostridioides difficile infection (CDI) is the leading cause of nosocomial diarrhea. Current diagnostic tools have difficulty distinguishing between…
biomarkers
The Potential of Hair Matrix for Biomarker Analysis in Schizophrenia
Abstract Schizophrenia (SCZ) is a complex psychiatric disorder with positive, negative, and cognitive symptoms that cause long-term functional impairment. Despite…
Thyroid differentiation score-related genes and prognostic model for thyroid cancer
Abstract Background: Thyroid differentiation score (TDS) reflects the differentiation degree of thyroid cancer (THCA). This study aimed to construct a…
Protein Kinase D1 (PRKD1) as a Diagnostic, Prognostic, and Immunomodulatory Biomarker in Human Cancers
Abstract Background and aim: Protein kinase D1 (PRKD1), a serine/threonine kinase, regulates cellular processes such as proliferation, apoptosis, migration, and…
The epiMelanoma test enables plasma-based detection of melanoma and prediction of immunotherapy response
Abstract Background: Melanoma is one of the most serious skin cancers worldwide, often progressing without obvious symptoms. Early detection is…
Multi-Modal Profiling Reveals Contrasting Immunomodulatory Effects of Recreational Marijuana Used Alone or with Tobacco in Youth with HIV
Abstract The evolving legal landscape has increased marijuana accessibility across the United States, including for medical use to manage clinical…
Cannabidiol Is Associated with Improved Survival in Pancreatic Cancer and Modulation of Bile Acids and Gut Microbiota
Abstract Pancreatic ductal adenocarcinoma (PDAC) is among the most aggressive malignancies, with dismal survival rates. Cannabinoids have shown anticancer properties…
Pan-cancer analysis of UGGT1 in human tumors and experimental validation in breast cancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-12619-x. Article type: Research Article Keywords: UGGT1, Cancer, Biomarker,…
The endocannabinoidome–gut microbiome–brain axis as a novel therapeutic target for autism spectrum disorder
Abstract Introduction: Autism spectrum disorder (ASD) is characterized by disruption of the gut–brain axis, which leads to behavioral, psychiatric, metabolic…
Prognostic and immunotherapeutic significance of NCAPD2 in pan-cancer and its role in hepatocellular carcinoma progression via the AKT/GSK-3β signaling pathway
Abstract Present studies indicated that NCAPD2 (Non-SMC condensin I complex subunit D2) has emerged as an essential participant of condensin…