Abnormalities of the endocannabinoid system produce piercing nuclear hernias in migrating cerebral neurons
Abstract We are reporting powerful streams of chromatin rupturing the nuclear envelope (NE) and the plasma membrane of migrating cerebral…
Biological sciences
How THC works: Explaining ligand affinity for, and partial agonism of, cannabinoid receptor 1
Abstract Interaction with cannabinoid receptor 1 (CB1) partially determines the bioactivity of the phytocannabinoids. Consequently, there has also been significant…
Edible cannabinoids impact meal structure and food impulsivity in female rats
Abstract Cannabinoid receptor agonists increase eating in a dose-dependent manner. However, the behavioral mechanisms by which cannabinoids modulate food intake…
Long-term consequences of adolescent exposure to the synthetic cannabinoid AB-FUBINACA in male and female mice
Abstract The consumption of synthetic cannabinoids during adolescence is reported to be a risk factor for the appearance of psychiatric…
The endocannabinoid system in the brain undergoes long-lasting changes following neuropathic pain
Abstract The endocannabinoid system (ECS), which is composed of endocannabinoids (eCBs), cannabinoid receptors (CBRs), and associated signaling molecules, has been…
LY-2183240 enhances reward-seeking behavior with inducing neuronal excitation and early apoptosis in mouse
Abstract Cannabinoids interact with cannabinoid receptors, influencing diverse central nervous system (CNS) and peripheral functions, including anxiety, depression, and cognition.…
Layer specific regulation of critical period timing and maturation of mouse visual cortex by endocannabinoids
Abstract Plasticity during the critical period is important for the functional maturation of cortical neurons. While characteristics of plasticity are…
AVERON notebook to discover actionable cancer vulnerabilities enabled by neomorph protein-protein interactions
Abstract Genomic alterations, such as missense mutations, often lead to the activation of oncogenic pathways and cell transformation by rewiring…
Inhibition of cannabinoid degradation enhances hippocampal contextual fear memory and exhibits anxiolytic effects
Abstract Recent studies have demonstrated the pivotal involvement of endocannabinoids in regulating learning and memory, but the conclusions obtained from…
Mitochondrial UQCC3 controls embryonic and tumor angiogenesis by regulating VEGF expression
Abstract Mitochondria play important roles in angiogenesis. However, the mechanisms remain elusive. In this study, we found that mitochondrial ubiquinol-cytochrome…