Multi-omics analyses of CD276 in pan-cancer reveals its clinical prognostic value in glioblastoma and other major cancer types
Abstract Background: CD276 (also known as B7-H3) is one of the most important immune checkpoints of the CD28 and B7…
bioinformatics
An approach for collaborative development of a federated biomedical knowledge graph-based question-answering system: Question-of-the-Month challenges
Abstract Knowledge graphs have become a common approach for knowledge representation. Yet, the application of graph methodology is elusive due…
A pan-cancer analysis of the prognostic value of long non-coding RNA LINC00662 in human cancers
Abstract Background: Numerous studies have revealed that the long non-coding RNA LINC00662 is irregularly expressed in various cancers, as well…
Validation of transcriptome signature reversion for drug repurposing in oncology
Abstract Transcriptome signature reversion (TSR) has been extensively proposed and used to discover new indications for existing drugs (i.e. drug…
Does the LHPP gene share a common biological function in pancancer progression?
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12920-022-01396-5. Article type: Research Article Keywords: LHPP, Tumor suppressor,…
The Inflammasomes Adaptor Protein PYCARD Is a Potential Pyroptosis Biomarker Related to Immune Response and Prognosis in Clear Cell Renal Cell Carcinoma
Abstract Simple Summary: Inflammation has been recognized as one of the hallmarks of cancers. PYCARD, the adaptor protein of inflammasomes,…
Multi‐omics analysis of the oncogenic value of copper Metabolism‐Related protein COMMD2 in human cancers
Abstract Background: The copper metabolism MURR1 domain (COMMD) protein family is involved in tumorigenicity of malignant tumors. However, as the…
The prognostic value of immune-related genes AZGP1, SLCO5A1, and CTF1 in Uveal melanoma
Abstract Objective: Uveal melanoma (UM) is an aggressive malignancy with a poor prognosis and no available effective treatment. Therefore, exploring…
Comprehensive pan-cancer analysis reveals the prognostic value and immunological role of SPIB
Abstract It is well-established that SPIB is essential for the survival of mature B cells, playing a key role in…
Pan-Cancer Analysis of the Immunological Role of PDIA5: A Potential Target for Immunotherapy
Abstract The aberrant protein disulfide isomerase A5 (PDIA5) expression was relevant to the poor prognosis of patients with human cancers.…