Abstract Neuropathic pain is a clinically challenging syndrome that is largely refractory to conventional therapies. It arises from lesions or…
Abstract The American Migraine Foundation estimates that over 39 million Americans and over 1 billion people worldwide suffer from some…
Abstract The negative effects of pain are a constant concern in the surgical management of animals, leading to the search…
Abstract Background: Some evidence suggests that cannabidiol (CBD) has potential to help alleviate HIV symptoms due to its antioxidant and…
Abstract Inflammatory bowel diseases (IBD) refer to a group of gastrointestinal (GI) disorders with complex pathogenesis characterized by chronic intestinal…
Abstract Background: The endocannabinoid 2-Arachidonyl glycerol (2-AG) exerts dose-related anti-nociceptive effects, which are potentiated by the related but inactive 2-palmitoyl…
Abstract The most common medicinal claims for cannabis are relief from chronic pain, stimulation of appetite, and as an antiemetic.…
Abstract Acutely, non-selective cannabinoid (CB) agonists have been shown to increase morphine antinociceptive effects, and we and others have also…
Abstract Extensive studies confirmed the role of adenosine in pain. All four subtypes of adenosine receptors contribute to antinociception, especially…
Abstract The Sterling Research Group identified pravadoline as an aminoalkylindole (AAI) non-steroidal anti-inflammatory pain reliever. As drug design progressed, the…