The Spicy Story of Cannabimimetic Indoles
Abstract The Sterling Research Group identified pravadoline as an aminoalkylindole (AAI) non-steroidal anti-inflammatory pain reliever. As drug design progressed, the…
antinociception and antiemesis
Effects of combined THC and heroin vapor inhalation in rats
Abstract Rationale: Opioids are effective medications, but they have several key limitations including the development of tolerance, establishment of dependence,…
Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems
Abstract Nausea and vomiting are common gastrointestinal complaints that can be triggered by diverse emetic stimuli through central and/or peripheral…
Evaluating the efficacy of cannabidiol to manage surgically induced neuropathic pain in a preclinical rat model: Are T cells a sexually dimorphic target?
Abstract Background: Considering the poorly understood etiology and complex symptoms of chronic neuropathic pain (NP), the lack of effective treatments,…
CB1 Agonism Alters Addiction-Related Behaviors in Mice Lacking Mu or Delta Opioid Receptors
Abstract Opioids are powerful analgesics but the clinical utility of these compounds is reduced by aversive outcomes, including the development…
Emerging Role of (Endo)Cannabinoids in Migraine
Abstract In this mini-review, we summarize recent discoveries and present new hypotheses on the role of cannabinoids in controlling trigeminal…
Suppression of Cisplatin-Induced Vomiting by Cannabis sativa in Pigeons: Neurochemical Evidences
Abstract Cannabis sativa (CS, family Cannabinaceae) has been reported for its anti-emetic activity against cancer chemotherapy-induced emesis in animal models…
Functional Role of Transient Receptor Potential Channels in Immune Cells and Epithelia
Abstract Transient receptor potential (TRP) ion channels are widely expressed in several tissues throughout the mammalian organism. Originally, TRP channel…
The Inhibitory Effects of Cobalt Protoporphyrin IX and Cannabinoid 2 Receptor Agonists in Type 2 Diabetic Mice
Abstract The activation of the transcription factor Nrf2 inhibits neuropathy and modulates the activity of delta-opioid receptors (DOR) in type…
TRP Channel Cannabinoid Receptors in Skin Sensation, Homeostasis, and Inflammation
Abstract In the skin, cannabinoid lipids, whether of endogenous or exogenous origin, are capable of regulating numerous sensory, homeostatic, and…