Methamphetamine Use in People Living with HIV: Clinical, Neurocognitive, and Blood Biomarker Profiles
Abstract Background: Methamphetamine (MA) use in people living with HIV (PLWH) has been linked to neurocognitive and behavioral dysregulation. We…
anti-neuroinflammation
Transient Receptor Potential Channels as Key Regulators of Neuroinflammation in Neurological Disorders: Mechanistic Insights, Therapeutic Potentials, and Future Directions
Abstract Background: Transient receptor potential (TRP) ion channels, a ubiquitous family of nonselective cation channels, are extensively expressed across the…
Metabolic toxicity and neurological dysfunction in methylmalonic acidemia: from mechanisms to therapeutics
Abstract Methylmalonic acidemia (MMAemia) is an inborn error of organic acid metabolism characterized by the accumulation of toxic metabolites—including methylmalonic…
Dual Role of the Spinal Endocannabinoid System in Response to Noxious Stimuli: Antinociceptive Pathways and Neuropathic Pain Mechanisms
Abstract Neuropathic pain is a clinically challenging syndrome that is largely refractory to conventional therapies. It arises from lesions or…
The microbiota–gut–brain axis in mental and neurodegenerative disorders: opportunities for prevention and intervention
Abstract The microbiota–gut–brain axis (MGBA) is increasingly recognized as a critical regulator of brain health, influencing both neurodevelopment and age-related…
Magnesium and Zinc in Schizophrenia
Abstract Schizophrenia is a severe recurrent chronic disease that affects a large number of patients. Numerous genetic and epigenetic factors…
Molecular pathogenesis of Alzheimer’s disease onset in a mouse model: effects of cannabidiol treatment
Abstract Introduction: Alzheimer’s disease (AD) is a common neurodegenerative condition involving a complex blend of disturbances in synaptic development and…
Phytochemical Modulators of Nociception: A Review of Cannabis Terpenes in Chronic Pain Syndromes
Abstract Cannabis sativa L. is a phytochemically rich plant with therapeutic potential across various clinical domains, including pain, inflammation, and…
Cannabidiol Effects on Depressive-like Behavior and Neuroinflammation in Female Rats Exposed to High-Fat Diet and Unpredictable Chronic Mild Stress
Abstract Depression and obesity are comorbid conditions linked through shared neuroinflammatory and immune mechanisms. This study examined the effects of…
Cannabinoid Receptors Reduced Early Brain Damage by Regulating NOX‐2 and the NLRP3 Inflammasome in an Animal Model of Intracerebral Hemorrhage
Abstract Background: Intracerebral hemorrhage (ICH) is a leading cause of death and disability worldwide. Following the initial mechanical injury caused…