Targeting non-apoptotic regulated cell death (RCD) to treat neurodegenerative diseases
Abstract Regulated cell death (RCD) is well-known as a controlled form of cell death regulated by one or more cascading…
anti-neuroinflammation
Epilepsy, neuroinflammation and cannabidiol What do we know thus far?
Abstract Epilepsy is a common neurological disorder associated with recurring seizures that in about one-third of individuals are resistant to…
Sex-dependent effects of ultra-low-dose-THC preventive treatment on neuroinflammation and cognitive decline in 5xFAD mice
Abstract Background: Alzheimer’s disease (AD) remains the most prevalent cause of dementia, yet no existing treatment effectively prevents its onset.…
Transient Receptor Potential Channels as Key Regulators of Neuroinflammation in Neurological Disorders: Mechanistic Insights, Therapeutic Potentials, and Future Directions
Abstract Background: Transient receptor potential (TRP) ion channels, a ubiquitous family of nonselective cation channels, are extensively expressed across the…
Therapeutic Potential for Cannabidiol on Alzheimer’s Disease-Related Neuroinflammation: A Systematic Review and Meta-Analysis
Abstract Alzheimer’s disease (AD) is a pervasive neurodegenerative disorder characterized by chronic neuroinflammation; current interventions primarily offer symptomatic relief. Cannabidiol…
Unraveling Cannabidiol’s Dual Modulatory Role in Schizophrenia: Network Pharmacology and In Vivo Validation of Neuroinflammatory and Behavioral Modulation
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s12035-025-05608-8. Article type: Research Article Keywords: Cannabidiol, Schizophrenia therapy,…
Metabolic toxicity and neurological dysfunction in methylmalonic acidemia: from mechanisms to therapeutics
Abstract Methylmalonic acidemia (MMAemia) is an inborn error of organic acid metabolism characterized by the accumulation of toxic metabolites—including methylmalonic…
The Endocannabinoid System in Human Disease: Molecular Signaling, Receptor Pharmacology, and Therapeutic Innovation
Abstract The endocannabinoid system (ECS) is a primary regulatory system in human physiology that serves to help maintain homeostasis throughout…
Tui Na Acupressure Modulates Treg Immunosuppression via FoxP3/mTORC1 Signalling in ALS Mice
Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease driven by neuroinflammation, where regulatory T cell (Treg) dysfunction exacerbates immune…
Dual Role of the Spinal Endocannabinoid System in Response to Noxious Stimuli: Antinociceptive Pathways and Neuropathic Pain Mechanisms
Abstract Neuropathic pain is a clinically challenging syndrome that is largely refractory to conventional therapies. It arises from lesions or…