A pan-cancer analysis of the oncogenic role of Keratin 17 (KRT17) in human tumors
Abstract Background: Although new evidence from cells or animals suggests a relationship between Keratin 17 (KRT17) and cancer, no pan-cancer…
Advanced cancer
Prognostic Value and Immunological Role of MORF4-Related Gene-Binding Protein in Human Cancers
Abstract MORF4-related gene-binding protein (MRGBP) is the subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation…
Cancer Therapy Challenge: It Is Time to Look in the “St. Patrick’s Well” of the Nature
Abstract Cancer still remains a leading cause of death despite improvements in diagnosis, drug discovery and therapy approach. Therefore, there…
Bioinformatics Analyses Reveal the Prognostic Value and Biological Roles of SEPHS2 in Various Cancers
Abstract Purpose: Selenophosphate synthetase 2 (SEPHS2) has been shown to regulate selenoprotein biosynthesis by catalyzing the synthesis of active selenium…
Glycolysis-related gene expression profiling serves as a novel prognosis risk predictor for human hepatocellular carcinoma
Abstract Metabolic pattern reconstruction is an important factor in tumor progression. Metabolism of tumor cells is characterized by abnormal increase…
Pan‐cancer analysis reveals the oncogenic role of 3‐hydroxy‐3‐methylglutaryl‐CoA synthase 1
Abstract Background: Emerging studies reveals that 3‐hydroxy‐3‐methylglutaryl‐CoA synthase 1 (HMGCS1) plays vital oncogenic roles in a broad spectrum of human…
Integrative pan-cancer analysis of MEK1 aberrations and the potential clinical implications
Abstract Alterations of mitogen-activated protein kinase kinase 1 (MEK1) are commonly associated with tumorigenesis, and MEK1 is thought to be…
Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace
Abstract The mTORC1 kinase complex regulates cell growth, proliferation, and survival. Because mis-regulation of DEPTOR, an endogenous mTORC1 inhibitor, is…
26S Proteasome Non-ATPase Regulatory Subunits 1 (PSMD1) and 3 (PSMD3) as Putative Targets for Cancer Prognosis and Therapy
Abstract Ever since the ubiquitin proteasome system was characterized, efforts have been made to manipulate its function to abrogate the…
Chromobox Homolog 8 (CBX8) in Human Tumor Carcinogenesis and Prognosis: A Pancancer Analysis Using Multiple Databases
Abstract Some emerging studies have suggested that chromobox homolog 8 (CBX8) may play a critical role in carcinogenesis and prognosis…