CD161, a promising Immune Checkpoint, correlates with Patient Prognosis: A Pan-cancer Analysis
Abstract Background: CD161 is a promising immune checkpoint mainly expressed on natural killer (NK) cells and is essential for immunoregulatory…
Advanced cancer
The Expression Profiles and Deregulation of UDP-Glycosyltransferase (UGT) Genes in Human Cancers and Their Association with Clinical Outcomes
Abstract Simple Summary: The human UDP-glycosyltransferase (UGT) superfamily plays a critical role in the metabolism of numerous endogenous and exogenous…
Galectins in Cancer and the Microenvironment: Functional Roles, Therapeutic Developments, and Perspectives
Abstract Changes in cell growth and metabolism are affected by the surrounding environmental factors to adapt to the cell’s most…
Pan-Cancer Analysis of Atrial-Fibrillation-Related Innate Immunity Gene ANXA4
Abstract Background: Atrial fibrillation (AF) is the most common tachyarrhythmia around the world. Cancer is one of the main causes…
A molecular taxonomy of tumors independent of tissue-of-origin
Abstract Cancer is an organism-level disease, impacting processes from cellular metabolism and the microenvironment to systemic immune response. Nevertheless, efforts…
Pan-cancer analysis of CXCR4 carcinogenesis in human tumors
Abstract Background: C-X-C chemokine receptor 4 (CXCR4) is a specific receptor of stromal cell-derived factor-1, also known as CXCL12. The…
The Endocannabinoid System: A Potential Target for the Treatment of Various Diseases
Abstract The Endocannabinoid System (ECS) is primarily responsible for maintaining homeostasis, a balance in internal environment (temperature, mood, and immune…
Pan-cancer analysis of the oncogenic role of discs large homolog associated protein 5 (DLGAP5) in human tumors
Abstract Background: In recent years, there have been many studies on the relationship between DLGAP5 and different types of cancers,…
Identification of key proteins in the signaling crossroads between wound healing and cancer hallmark phenotypes
Abstract Wound healing (WH) and cancer seem to share common cellular and molecular processes that could work in a tight…
A pan-cancer analysis revealed the role of the SLC16 family in cancer
Abstract Cancer is one of the serious diseases that endanger human health and bring a heavy burden to world economic…