An fMRI analysis of verbal and non-verbal working memory in people with a past history of opioid dependence
Abstract Introduction: Working memory describes the ability to maintain and manipulate information held in mind, and it is a fundamental…
Addiction Medicine
Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats
Abstract Rationale: The endocannabinoid system makes critical contributions to reward processing, motivation, and behavioral control. Repeated exposure to THC or…
The Inflammatory Signals Associated with Psychosis: Impact of Comorbid Drug Abuse
Abstract Psychosis and substance use disorders are two diagnostic categories whose association has been studied for decades. In addition, both…
Sex Differences in the Neuropsychiatric Effects and Pharmacokinetics of Cannabidiol: A Scoping Review
Abstract Cannabidiol (CBD) is a non-intoxicating cannabinoid compound with diverse molecular targets and potential therapeutic effects, including effects relevant to…
Exploring the Role of DARPP-32 in Addiction: A Review of the Current Limitations of Addiction Treatment Pathways and the Role of DARPP-32 to Improve Them
Abstract We are amidst a global addiction crisis, yet stigmas surrounding addiction counterintuitively prevail. Understanding and appreciating the neurobiology of…
Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions
Abstract During adolescence, frequent and heavy cannabis use can lead to serious adverse health effects and cannabis use disorder (CUD).…
Daily Δ9-Tetrahydrocannabinol and Withdrawal Increase Dopamine D1-D2 Receptor Heteromer to Mediate Anhedonia- and Anxiogenic-like Behavior Through a Dynorphin and Kappa Opioid Receptor Mechanism
Abstract Background: Frequent cannabis use is associated with a higher risk of developing cannabis use disorder and other adverse consequences.…
Consideration of sex and gender differences in addiction medication response
Abstract Substance use continues to contribute to significant morbidity and mortality in the United States, for both women and men,…
Medicinal Cannabis and Central Nervous System Disorders
Abstract Cannabinoids, including those found in cannabis, have shown promise as potential therapeutics for numerous health issues, including pathological pain…
Expert advice for prescribing cannabis medicines for patients with epilepsy—drawn from the Australian clinical experience
Abstract There is international interest for consensus advice for prescribers working in the field of drug resistant epilepsy intending to…