Skin on Drugs: Psychotropic Compounds in Cutaneous Biology
Abstract Recent evidence reveals that several psychotropic compounds exert significant biological effects on the skin through neurochemical and immunomodulatory pathways.…
acute inflammation
Anti‐Inflammatory Potential of Key Phytochemicals From Humboldtia sanjappae: In Vivo Studies and Molecular Docking With MM‐GBSA Analysis
Abstract Humboldtia sanjappae, an endemic medicinal plant, was examined for its anti‐inflammatory properties using both in vivo and in silico…
Cannabis Oil Prevents Early Hepatic Fibrosis, Inflammation, and Endothelial Dysfunction in a Sucrose-Rich Diet-Induced MASLD Model: Role of Cannabinoid Receptors
Abstract Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a growing health concern globally, often associated with excessive sugar intake…
Metabolic Responses of Melanocytes and Melanoma Cells to UVA Radiation and Phytocannabinoids Exposure
Abstract Ultraviolet A (UVA) radiation disrupts the redox balance of melanocytes and may lead to the development of melanoma, highlighting…
Discovery of a novel cannabidiol-derived transient receptor potential vanilloid 4 inhibitor to reduce pulmonary edema and lung vascular permeability in mice
Abstract Introduction: Activation of TRPV4 ion channel during acute lung injury (ALI) exacerbates lung dysfunction by promoting edema and inflammation.…
Cannabidiol and other non-psychotropic cannabinoids from Cannabis sativa as therapeutics for microglial-mediated neuroinflammation and neurodegeneration
Abstract Non-psychotropic phytocannabinoids produced by Cannabis sativa, including cannabidiol, cannabigerol, cannabichromene and their varin and acidic analogs, are emerging as…
Immunomodulatory effects of cannabis use: a multi-omics study in people living with HIV
Abstract Background: Cannabis is one of the most commonly used substances worldwide. Cannabinoids are known to have anti-inflammatory effects. However,…
Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells
Abstract Background: Canine mammary carcinoma (CMC) is characterised by a chronic inflammatory microenvironment resembling human breast cancer; however, the upstream…
Hematological Inflammatory Indices and Coagulation Parameters in Individuals with Substance Use Disorder: A Comparative Study with Healthy Controls
Abstract Background: Substance use disorder (SUD) is associated with systemic inflammatory activation and may influence hematological and coagulation-related pathways. Chronic…
Cytotoxic Effects of the Synthetic Cannabinoid, 5F-MDMB-PICA on Human Glioblastoma U87-MG Cells
Abstract Synthetic cannabinoids, particularly 5F-MDMB-PICA, have emerged as potent psychoactive substances, exhibiting a binding affinity to the CB1 receptor approximately…