Anti-inflammatory and analgesic potential of minor cannabinoids in vivo
Abstract Background: The cannabis plant produces many bioactive compounds, including the major cannabinoids THC and CBD, and many lesser studied…
acute inflammation
The dual roles of natural cannabidiol in combating oxidative stress and inflammation: A potential intestinal guardian
Abstract Cannabidiol (CBD), a non-psychoactive and non-addictive phytocannabinoid derived from Cannabis sativa L., has attracted increasing attention for its therapeutic…
Cannabidiol mitigates high-fat-diet-induced early-stage inflammation in two adipose tissue fat depots of Wistar rats
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-36666-0. Article type: Research Article Keywords: Adipose tissue, Cannabidiol,…
Therapeutic potential of acidic cannabinoids: an update
Abstract Cannabis sativa yields a wide range of bioactive compounds, including terpenes, flavonoids, and cannabinoids. Tetrahydrocannabinolic acid (THCA), cannabidiolic acid…
Fecal microbiota transplantation to reduce immune activation in ART-treated people with HIV with low CD4/CD8 ratio: protocol for the single-blind, randomized, placebo-controlled Gutsy study (CIHR/CTN PT038)
Abstract Background: Despite antiretroviral therapy (ART) controlling HIV viral replication, people with HIV (PWH) remain at risk for inflammatory non-AIDS…
Biological sex modulates lung injury severity in adolescent mice exposed to short‐term aerosolized vitamin E acetate
Abstract The E‐cigarette or Vaping product‐Associated Lung Injury (EVALI) causes severe acute respiratory failure and, in some cases, death. Most…
Cannabidiol reduces LPS-induced inflammatory response in the human placenta by reducing NF-κB translocation
Abstract Background: Cannabidiol (CBD), a non-psychoactive cannabinoid increasingly used during pregnancy, has been proposed to modulate inflammatory processes. However, its…
Insights into cannabinoid receptor 2 (CB2) anterograde trafficking and pharmacological chaperoning
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00018-025-05961-w. Article type: Research Article Keywords: Receptor, cannabinoid, Cannabinoid…
Effect of Central Injection of Anandamide on LPS-Dependent Suppression of GnRH/LH Secretion in Ewes During the Follicular Phase of the Estrous Cycle
Abstract The study investigated the effects of intracerebroventricular (ICV) administration of the endocannabinoid anandamide (AEA) on suppression of gonadotropin-releasing hormone…
Efficacy of cannabis oil on appetite and quality of life in systemic sclerosis patients: a randomized placebo-controlled trial
Abstract Background: The efficacy of cannabinoids as appetite stimulants in chronic wasting disorders is well established; however, their role in…