Cannabinoid Receptor 2 (CB2) in Macrophages: A Promising Clinical Target for Immune Disorders
Abstract Macrophages are essential for immune homeostasis, playing crucial roles in immune responses from initiation to resolution. They trigger acute…
acute inflammation
Microglial activation is inhibited by selective anti-seizure medications
Abstract Objective: To investigate the anti-inflammatory properties of anti-seizure medications (ASMs) administered to patients with drug-resistant epilepsy (DRE) and the…
Biotechnological potential of Cannabis sativa adventitious roots for producing immunomodulatory and anti-inflammatory bioactive compounds
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-16130-1. Article type: Research Article Keywords: Adventitious roots, Dendritic…
Cannabidiol Enhances the Therapeutic Efficacy of Olsalazine and Cyclosporine in a Murine Model of Colitis
Abstract Current therapies for inflammatory bowel disease (IBD), such as olsalazine and cyclosporine, often exhibit limited long-term efficacy and are…
Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application Prospects
Abstract Palmitoylethanolamide (PEA) has attracted increasing attention from researchers as an endogenous lipid mediator. It exhibits a unique mechanism of…
Loganic acid ameliorates diabetic cardiomyopathy via suppressing TLR4/p38 MAPK signaling-mediated oxidative stress and inflammation
Abstract Diabetic cardiomyopathy (DCM), a life-threatening cardiovascular complication of diabetes, manifested as progressive cardiac dysfunction mediated through oxidative stress, inflammation,…
Hybrid Cannabis sativa L. inflorescences exert an anti-inflammatory effect through the modulation of MAPK/NF-κB/NLRP3 inflammasome and JAK1/STAT6 pathway in HaCaT cells
Abstract Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease accompanied by severe itching. Reducing mediators of skin inflammation…
Novel hematologic ratios and systemic inflammation index in ADHD: effects of methylphenidate treatment
Abstract Background: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, and recent research suggests systemic inflammation contributes to its pathophysiology.…
Targeting Vascular and Inflammatory Crosstalk: Cannabigerol as a Dual-Pathway Modulator in Rosacea
Abstract Rosacea is a chronic inflammatory skin condition characterized by persistent erythema and abnormal vascular response. Although current treatments focus…
Antinociceptive and Anti‐inflammatory Effect of Nicandrin B Isolated From Datura ferox in Zebrafish
Abstract Nicandrin B (Nic B), a withanolide isolated from Datura ferox leaves, was investigated for its antinociceptive and anti‐inflammatory effects…