YBX1 Expression Marks Proliferative Tumour States with Context-Dependent Genomic Instability: A Pan-Cancer Analysis
Abstract Y-box binding protein 1 (YB-1; encoded by YBX1) is a multifunctional DNA- and RNA-binding protein implicated in cell cycle…
Science Article
Identification of Changes in the Transcriptome Profile of Human Hepatoma HepG2 Cells Exposed to Combined Sorafenib and Cannabis Treatment
Abstract Cannabis-derived compounds are increasingly used as adjuncts in cancer therapy due to their reported antiproliferative and pro-apoptotic effects. However,…
Genetic Pathways Point to the Biology Underlying the Association Between Cannabis Use Disorder and Psychosis
Abstract Background: Cannabis use is associated with increased risk of psychotic disorders, but the underlying biological mechanisms remain unclear. We…
Cannabinoids in Alzheimer’s disease: animal–human evidence and clinical pharmacology challenges
Abstract Cannabinoids have emerged as potential modulators of pathological processes in Alzheimer’s disease (AD), including neuroinflammation, synaptic dysfunction, and protein…
Formulation-specific dose–response in the serum proteome of healthy dogs following cannabidiol administration
Abstract Cannabidiol (CBD) is increasingly being used in veterinary medicine; however, its systemic molecular effects in dogs remain poorly characterized.…
Direct modulation of human GABA-A α1β2γ2 receptors by the endocannabinoid 2-arachidonoylglycerol: implications for cannabinoid-related ligands and limitations for anxiolytic drug development
Abstract Anxiety disorders are associated with impaired inhibitory neurotransmission mediated by γ-aminobutyric acid type A (GABA-A) receptors. Although benzodiazepines remain…
Suicide attempts among youth attending special education centres: risk and protective factors
Abstract Purpose: Adolescents studying in special education centres are a group at particular risk of suicidal behaviour. The aim of…
Integrative network analysis reveals organizational principles of the endocannabinoid system
Abstract Background: The endocannabinoid system (ECS) is a complex signaling network that regulates diverse physiological processes, including pain, mood, metabolism,…
Cannabidiol and other non-psychotropic cannabinoids from Cannabis sativa as therapeutics for microglial-mediated neuroinflammation and neurodegeneration
Abstract Non-psychotropic phytocannabinoids produced by Cannabis sativa, including cannabidiol, cannabigerol, cannabichromene and their varin and acidic analogs, are emerging as…
Integrated pan cancer analysis with breast cancer validation identifies SEC13 homolog as prognostic biomarker and immunotherapy target
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-52775-2. Article type: Research Article Keywords: Pan-cancer, Prognosis, Diagnosis,…