Insights into the molecular mechanisms underlying the function of lysyl oxidase like 1 in cancers
Abstract Cancer is one of the primary causes of human mortality and a significant barrier to increasing human life expectancy.…
Science Article
Clinically Meaningful Reduction in Drop Seizures in Patients with Lennox–Gastaut Syndrome Treated with Cannabidiol: Post Hoc Analysis of Phase 3 Clinical Trials
Abstract Background and Objective: In clinical trials of patients with Lennox–Gastaut syndrome (LGS), a ≥ 50% reduction in drop seizure…
Chemical Profiling of Volatile and Non‐Volatile Fractions of Galbanum (Ferula galbaniflua Boiss.) Used in Perfumery
Abstract Galbanum (Ferula galbaniflua Boiss.) is a valuable fragrance ingredient used in fine perfumery for its green, woody, balsamic, bell…
DPPH‐based Antioxidant Screening and Cellulase‐assisted Hydrodistillation of Matourea azurea: Improved Essential Oil Yield and Density Functional Theory Insights Into a Rare Terpene
Abstract Essential oils are rich in bioactive molecules like terpenes and phenolic compounds, but have low yields, making process efficiency…
Transcriptional patterns of cancer-related genes in primary and metastatic tumours revealed by machine learning
Abstract Background: A key to understanding cancer is to determine the impact on the cellular pathways caused by the repertoire…
Machine learning derived development and validation of extracellular matrix related signature for predicting prognosis in adolescents and young adults glioma
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-13547-6. Article type: Research Article Keywords: Adolescents and young…
Enhancing image retrieval through optimal barcode representation
Abstract Data binary encoding has proven to be a versatile tool for optimizing data processing and memory efficiency in various…
ITGAV as a promising diagnostic, immunological, and prognostic biomarker in pan-cancer
Abstract Integrin αV (ITGAV) plays a key role in cell adhesion, migration, and immune regulation, and is implicated in tumor…
TRP channels in hepatocellular carcinoma: integrative Mendelian randomization and multi-omics analyses highlight MCOLN3/TRPV4 as candidate dual-effect biomarkers
Abstract Background: The causal relationship between Transient receptor potential (TRP) and hepatocellular carcinoma (HCC) remains unclear. Our study aimed to…
Pharmacological advances in cannabinoid-based therapies for pancreatic cancer: preclinical efficacy of CCL-106 and its epimers
Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal form of cancer with limited treatment options and poor…