Insights into the molecular mechanisms underlying the function of lysyl oxidase like 1 in cancers
Abstract Cancer is one of the primary causes of human mortality and a significant barrier to increasing human life expectancy.…
Science Article
Clinically Meaningful Reduction in Drop Seizures in Patients with Lennox–Gastaut Syndrome Treated with Cannabidiol: Post Hoc Analysis of Phase 3 Clinical Trials
Abstract Background and Objective: In clinical trials of patients with Lennox–Gastaut syndrome (LGS), a ≥ 50% reduction in drop seizure…
Chemical Profiling of Volatile and Non‐Volatile Fractions of Galbanum (Ferula galbaniflua Boiss.) Used in Perfumery
Abstract Galbanum (Ferula galbaniflua Boiss.) is a valuable fragrance ingredient used in fine perfumery for its green, woody, balsamic, bell…
DPPH‐based Antioxidant Screening and Cellulase‐assisted Hydrodistillation of Matourea azurea: Improved Essential Oil Yield and Density Functional Theory Insights Into a Rare Terpene
Abstract Essential oils are rich in bioactive molecules like terpenes and phenolic compounds, but have low yields, making process efficiency…
Transcriptional patterns of cancer-related genes in primary and metastatic tumours revealed by machine learning
Abstract Background: A key to understanding cancer is to determine the impact on the cellular pathways caused by the repertoire…
Effectiveness of an educational asthma management program (CuidAR): the protocol for a cluster-randomized trial in the Brazilian primary healthcare setting
Abstract Background: Asthma is one of the most prevalent chronic pulmonary diseases, affecting approximately 20 million Brazilian people. Most patients…
Randomized single-dose crossover comparative bioavailability study of two novel oral cannabidiol (CBD) formulations in healthy volunteers under fed conditions, compared to a standard CBD isolate capsule
Abstract Background: This study aimed to compare the pharmacokinetics and relative bioavailability of two novel cannabidiol (CBD) formulations including bioavailability-enhanced…
Cannabidiol Suppresses EMT in Pancreatic Cancer via Inhibition of MALAT1 lncRNA and PI3K/Akt/mTOR Signaling Pathway
Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by aggressive metastasis and poor response to chemotherapy, largely driven by epithelial–mesenchymal transition…
Antibacterial and Antibiofilm Activity of 8‐Hydroxyquinoline Derivatives Against Mycobacterium and Staphylococcus Species
Abstract A series of 8‐alkoxyquinoline derivatives (QD‐1–12) were designed and synthesized on the basis of analogues of 8‐hydroxyquinoline (8‐HQ) (HQ…
RAB5B: explore its carcinogenic potential and understand its role, prognostic value and biological significance in pan-cancer
Abstract Background: The RAB5B protein belongs to the RAB family and is primarily localized to early endosomes. It regulates the…