Synthetic cannabinoids in e‐cigarettes seized from English schools
Abstract Background and aims: People who use synthetic cannabinoids (SCs) report debilitating side effects and withdrawal symptoms, coupled with dependence.…
Science Article
Exogenous Administration of Delta-9-Tetrahydrocannabinol Affects Adult Hippocampal Neurotransmission in Female Wistar Rats
Abstract Delta-9-tetrahydrocannabinol (THC) is a psychoactive element of Cannabis sativa and affects the human cannabinoid system through its receptors, CB1R…
Distinct Interactions of Cannabinol and Its Cytochrome P450-Generated Metabolites with Receptors and Sensory Neurons
Abstract Interest in nonpsychotropic cannabinoids like cannabinol (CBN) is increasing for pain therapy. This study delivers critical insights into CBN’s…
Synthesis, Characterization, Biological Evaluation, DFT Calculations, and Molecular Docking Study of Transition Metal Complexes Derived From a Schiff Base Ligand
Abstract The escalating global challenge of antibiotic resistance amid rising oxidative stress emphasizes the critical necessity for innovative antimicrobial strategies.…
PCNA in Pan-Cancer: A Prognostic Biomarker Unveiled Through a Data-Driven, Multidimensional Analysis of Transcriptomics, Immunity, and Functional Profiling
Abstract Proliferating cell nuclear antigen (PCNA) is a central regulator of numerous cellular processes impacting DNA metabolism and genetic integrity,…
Lifespan investigation of brain volumetric changes associated with substance use disorders
Abstract Substance use disorder (SUD) stands as a critical public health concern, contributing to substantial morbidity, mortality and societal costs.…
How to ESCAPE from Pain? An Observational Study on Improving Pain and Quality of Life with the Cannamedical® Hybrid Cannabis Extract
Abstract Introduction: Chronic pain remains a challenge, with standard therapies often providing inadequate pain relief and causing undesirable side effects.…
Chemical Composition and In Vitro Antibiofilm Action of Varronia curassavica Jacq. (Boraginaceae) Essential Oil: A Promising Natural Agent Against Bacterial Infections
Abstract Antimicrobial resistance is an increasing threat to public health, with alarming estimates of mortality rates. In this context, the…
Target Mapping in Cancer: Ligandable Protein Pockets on 3D OncoPPI Networks
Abstract Background/Objectives: Studying protein–protein interaction (PPI) networks is crucial in understanding cancer phenotypes and molecular mechanisms. Here, we focus on…
Multidimensional analysis suggests that ZNF433 is a promising biomarker for the diagnosis and prognosis of human cancers
Abstract Background: Zinc finger proteins, particularly members of the Krüppel-associated box zinc finger proteins (KRAB-ZFPs), play critical roles in regulating…