Exploring ASPN as a pan-cancer biomarker with a focus on gastric cancer
Abstract Background: Cancer remains a leading cause of mortality worldwide, posing a serious threat to public health. The ASPN protein…
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DOCK2 modulates immune checkpoint inhibitor responsiveness and prognosis in cutaneous melanoma through multi-omics and single-cell T cell dynamics profiling
Abstract Background: Skin cutaneous melanoma (SKCM) is a highly aggressive malignancy that arises from melanocytes and has been associated with…
Cannabidiol in pancreatic ductal adenocarcinoma: preclinical evidence, molecular mechanisms, and translational challenges
Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest and most treatment-resistant cancers, with limited progress in improving…
Data-driven universal insights into tumorigenesis via hallmark networks
Abstract Cancers are complex diseases characterized by dynamic perturbations of regulatory networks across multiple hierarchical levels, which cannot be fully…
Long-term safety and tolerability of transdermal cannabidiol gel in children and adolescents with Fragile X syndrome (ZYN2-CL-017): an interim analysis of an ongoing open-label extension study
Abstract Background: Dysregulated endocannabinoid signaling is involved in Fragile X syndrome (FXS), suggesting a potential role for the endocannabinoid signaling…
Using a PBPK Model Incorporating Lymphatic Absorption to Predict Food Effect, Multiple Dosing, and Hepatic Impairment of Cannabidiol
Abstract Cannabidiol (CBD) is one of the most extensively studied cannabinoids and is used for myriad conditions. Its oral pharmacokinetics…
Integrated bulk and single-cell transcriptomic profiling reveals NECTIN–TIGIT interaction underlies T cell exhaustion in papillary thyroid carcinoma
Abstract To elucidate the immunological mechanisms underlying T cell exhaustion in papillary thyroid carcinoma (PTC) by integrating bulk and single-cell…
Anti-Müllerian hormone plays a bidirectional role in cancer: a multi-database and multi-method study
Abstract Introduction: Anti-Müllerian hormone (AMH) has been variably associated with cancer risk. This study integrated a meta-analysis, Mendelian randomization (MR),…
A pan-cancer analysis of the oncogenic role of KDELR2 in human cancers
Abstract Background: KDELR2, a retrograde transport receptor involved in ER protein homeostasis, has emerged as a potential contributor to cancer…
Environmental behavior and human health risks of PFAS: occurrence, toxicity, and the state-of-the-art removal approaches
Abstract Fluorinated compounds, including poly- and per-fluoroalkyl substances (PFAS), are characterized by complex behavior, environmental persistence, and resistance to degradation.…