TIMELESS deficiency sensitizes thyroid cancer to cisplatin treatment via the DNA damage repair pathway
Abstract DNA damage repair (DDR) pathway was activated in thyroid cancer under cisplatin treatment. TIMELESS, a circadian rhythm gene, was…
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Potential of Cannabidiol (CBD) to overcome extensively drug-resistant Acinetobacter baumannii
Abstract Supplementary Information: The online version contains supplementary material available at 10.1186/s12906-025-05056-w. Article type: Research Article Keywords: Antimicrobial resistant, Cannabidiol,…
Effectiveness of prophylactic pancreatic stents in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis in high-risk patients: a 16-year comprehensive study
Abstract Background: Cannulation of the common bile duct (CBD) during endoscopic retrograde cholangiopancreatography (ERCP) can be technically challenging, especially when…
SLPI as a dedifferentiation biomarker in BRAFV600E-mutant papillary thyroid cancer
Abstract The BRAFV600E mutation drives papillary thyroid carcinoma (PTC) progression and therapy resistance, yet its downstream effectors remain incompletely characterized.…
Conservative Management Versus Early Cholecystectomy for Gallstone Disease: A Meta‐Analysis of Randomized Controlled Trials
Abstract Objective: While most individuals with gallstone disease remain asymptomatic, symptoms of gallstone disease range from biliary pain to acute…
Palmitoylethanolamide in the Treatment of Pain and Its Clinical Application Prospects
Abstract Palmitoylethanolamide (PEA) has attracted increasing attention from researchers as an endogenous lipid mediator. It exhibits a unique mechanism of…
Multidimensional pan cancer analysis of the sodium induced cell death gene TRPM4
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-15082-w. Article type: Research Article Keywords: TRPM4, Sodium-induced cell…
Investigation of the combined effects of cannabidiol plus naltrexone on alcohol craving in alcohol dependence: study protocol of a phase II randomised, double-blind, placebo-controlled, parallel-group trial – ICONICplus Trial
Abstract Introduction: Alcohol dependence (AD) is highly prevalent and has severe consequences on health and quality of life. However, the…
Effects of cannabidiol to circadian period, sleep, life span, close-proximity rhythm, egg reproduction and motor function in Drosophila melanogaster
Abstract Cannabidiol (CBD), a non-psychoactive cannabinoid, has been studied for its various health-promoting effects recently. This study investigates the effects…
α‑Glucosidase Inhibitors from the Leaves of Cannabis sativa: Structure–Activity Relationship, Kinetic Investigation, and Molecular Docking
Abstract Cannabis sativa L. is a valuable agricultural crop, extensively utilized in various fields and comprising diverse chemical constituents. In…