The Anti-proliferative Effects of Anandamide and Oleamide in Glioblastoma Cell Lines Recruit Mitochondrial and PPAR-γ Receptor Modulation

Abstract Graphical Abstract: The endocannabinoids AEA, and its related compound ODA, decrease cell viability and proliferation in C6 and RG2 glioblastoma cells by inducing mitochondrial stress. Depending on the phenotypic and metabolic features of the GB cell line, PPAR-γ receptor can induce anti-proliferative effects mediated by eCB. ODA and AEA exert different mechanisms depending on the cell line; in C6, lipoperoxidation, a decrease in mitochondrial membrane potential, and inhibition of mitochondrial complex I are predominant, while in RG2, sensitivity to