Natural Product-Derived Activity-Based and Affinity-Based Probes: Tools for Mechanism of Action Studies
Abstract Natural products have played a pivotal role in the history of drug discovery, yet mechanistic investigations have often posed…
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Stellate Ganglion Block for the Management of Cannabis Use Disorder: A Case Series
Abstract Currently, there are no approved or consistently effective pharmacological treatments for managing cannabis use disorder. Three patients diagnosed with…
Cannabidiol (CBD) Induces Lipid Microdomain Disruption or Budding in Ternary Mixtures
Abstract CBD, one of the main phytocannabinoids present in Cannabis sativa, is a singular and promising molecule in medicine, as…
Effects of Green Light Deprivation and Red-to-Blue Ratio on Growth, Mineral Content, and Pigments in Salvia officinalis L. and Cannabis sativa L.
Abstract Light spectral composition plays a central role in regulating plant growth, morphology, nutrient uptake, and pigment biosynthesis, particularly in…
Selective TRPV2 Antagonists Derived from the Natural Product Piperlongumine Inhibit Cancer Cell Migration and Metastasis
Abstract TRPV2 is the least studied member of the vanilloid TRP subfamily despite its emerging relevance in cancer metastasis, pain,…
A multifunctional conductive physiomimetic scaffold: synergy of rGO coating and cannabis-derived nanotopography for infection-resistant bone repair
Abstract Conventional bone grafts cannot reliably fulfill the dual requirements of rapid osseoinduction and intrinsic infection-resistance to meet clinical needs.…
Topical application of cannabidiol for muscle recovery after exercise-induced muscle damage: a randomized, double-blinded pilot study
Abstract Introduction: This study investigated the effects of a topical cannabidiol (CBD) gel compared to placebo on muscle function recovery,…
Natural Hydrophobic Deep Eutectic Solvent-Based Enhanced Extraction of Bioactive Compounds from Cannabis sativa L. Leaf for Pharmaceutical Applications
Abstract Cannabis sativa L. leaves (CSL) are a rich in bioactive compounds and known for their medicinal and recreational uses.…
Real-Time and Long-Term Effects of Medical Marijuana on Older Adults: Protocol for a Prospective Cohort Study
Abstract Background: Older adults represent the fastest-growing group of medical marijuana (MM) users in the United States, with chronic pain…
A novel enema formulation containing cannabidiol and sodium propionate for ulcerative colitis: preclinical assessment in a murine model
Abstract Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by mucosal inflammation, epithelial barrier disruption, and immune…