Impact of Cannabidiol and Its Synthetic Derivative on Fentanyl Consumption and Fentanyl-Induced Neurometabolic Alterations in Mice

Dalal A. AlKhelb, Jomana M. Alahmadi, Maisa S. Alqarni, Syed Rizwan Ahamad, Alaa Alnoor Alameen, Ahmed Altuwaijri +2 more

Background: Opioid use disorder (OUD) remains a critical global health challenge, with highly potent synthetic opioids like fentanyl contributing to overdose deaths. The available treatments have limitations. The endocannabinoid system has emerged steadily as a therapeutic target for the opioid crisis due to its modulatory effects on opioid reward and withdrawal and its involvement in regulating inflammation. Thes…