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Research Article 2016CC BY-NCFree full text · non-commercial reuse

Loss of Either Rac1 or Rac3 GTPase Differentially Affects the Behavior of Mutant Mice and the Development of Functional GABAergic Networks.

Roberta Pennucci, Francesca Talpo, Veronica Astro, Valentina Montinaro, Lorenzo Morè, Marco Cursi +10 more

Rac GTPases regulate the development of cortical/hippocampal GABAergic interneurons by affecting the early development and migration of GABAergic precursors. We have addressed the function of Rac1 and Rac3 proteins during the late maturation of hippocampal interneurons. We observed specific phenotypic differences between conditional Rac1 and full Rac3 knockout mice. Rac1 deletion caused greater generalized hyperac…

Cerebral Cortex (New York, NY)Europe PMC

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Research Article 2012CC BYFree full text

Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells.

Hao-Ping Liu, Chia-Chun Chen, Chih-Ching Wu, Yi-Chuan Huang, Shu-Chen Liu, Ying Liang +2 more

Epstein-Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC), a human malignancy notorious for its highly metastatic nature. Among EBV-encoded genes, latent membrane protein 1 (LMP1) is expressed in most NPC tissues and exerts oncogenicity by engaging multiple signaling pathways in a ligand-independent manner. LMP1 expression also results in actin cytoskeleton reorganization, which modulates…

PLoS Pathogens