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Research Article 2025CC BYFree full text

Effects of marijuana and tobacco on male fertility and their relationship to genetic variation of mitochondrial cytochrome C oxidase genes.

Houda Amor, Ayham Ismaeil, Peter Michael Jankowski, Mohammad A Al Smadi, Mazhar S Al Zoubi, Ingolf Juhasz-Böss +1 more

Although tobacco smoking declined among men at reproductive age, the use of cannabis increased. The aim of our study was to determine the impact of tobacco and cannabis on sperm quality, sperm DNA integrity tested by Chromomycin A3 (CMA3) and acridine orange (AO) and their association to genetic variants in the Cytochrome C Oxidase 1, 2 and 3 genes (MT-CO1, MT-CO2, and MT-CO3). Semen samples were collected and div…

Scientific Reports Europe PMC

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Research Article 2020CC0Free full text

Associations of mitochondrial genomic variation with corticobasal degeneration, progressive supranuclear palsy, and neuropathological tau measures.

Rebecca R Valentino, Nikoleta Tamvaka, Michael G Heckman, Patrick W Johnson, Alexandra I Soto-Beasley, Ronald L Walton +5 more

Mitochondrial health is important in ageing and dysfunctional oxidative phosphorylation (OXPHOS) accelerates ageing and influences neurodegeneration. Mitochondrial DNA (mtDNA) codes for vital OXPHOS subunits and mtDNA background has been associated with neurodegeneration; however, no study has characterised mtDNA variation in Progressive supranuclear palsy (PSP) or Corticobasal degeneration (CBD) risk or pathogene…

Acta Neuropathologica Communications