Interaction of β-Caryophyllene with a Simplified Membrane Model and Its Growth-Inhibitory Effect Against Escherichia coli ATCC 25922

Noé Luiz-Santos, Juan Luis Morales-Landa, Jesús Carlos Ruiz-Suárez, Estefania Lazcano-Díaz

The increasing prevalence of antimicrobial resistance in bacteria highlights the need for alternative membrane-active compounds with favorable safety profiles. β-Caryophyllene (BCP), a bicyclic sesquiterpene, has demonstrated antimicrobial effects; however, its biological responses in Gram-negative bacteria and associated membrane interactions remain insufficiently characterized. In this study, the growth inhibito…