Cannabinoids in hematologic malignancies: mechanisms and therapeutic potential for overcoming drug resistance

Sixu Li, Xiaokun Jian, Yufu Tang, Zhentao Wang, Tianjiao Min, Luyao Yu +2 more

Hematologic malignancies are highly heterogeneous diseases in which the emergence of therapy resistance remains a major obstacle to durable clinical benefit. Cannabinoids, acting through the endocannabinoid system, have drawn increasing interest because of their potential to modulate multiple resistance-associated pathways, yet the available evidence remains fragmented across disease entities, experimental models,…