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Research Article 2025CC BYFree full text

SIRT1 retention in elongating spermatids interferes with histone displacement by counteracting MOF-dependent H4K16 acetylation.

Veronica Porreca, Teresa Chioccarelli, Francesco Albano, Valeria Nittoli, Giulia Ricci, Concetta Ambrosino +7 more

Introduction The histone H4 hyperacetylation (i.e., acetylation of H4 at lysines -K5, -K8, -K12, and -K16, here reported as H4tetraAc) occurs in elongating spermatids (eSPTs) during spermiogenesis. Although it is critically involved in histone displacement, the mechanistic involvement of histone -acetyltransferases (HATs) and -deacetylases (HDACs) in the pathway underlying H4 hyperacetylation is poorly defined. He…

Frontiers in Cell and Developmental Biology Europe PMC

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Research Article 2025CC BYFree full text

Exercise ameliorates stanozolol and cannabis co-abuse testicular damage in rats evidenced by biochemical and histological regulation of SIRT1 and STS.

Shaimaa ElShebiney, Noha A. Mowaad, Rania Elgohary, Marwa E. Shabana, Rasha S. El-Mahdy, Asmaa M. Elfiky

Polydrug use among teenagers is widespread and emergent either among athletes or non-athletes. It is reported that stanzolol (Stanz) is commonly abused with cannabis (Cann), this combination probably affects the testicular functions negatively. Aim The present study aimed to evaluate the toxic effects of Stanz and or Cann on reproductive hormones and testicular enzymes. Male Wistar rats were administered Stanz (5…

Scientific Reports Europe PMC

Research Article 2021CC BYFree full text

Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway.

Lu Li, Xiaoxi Liu, Shasha Li, Qingyan Wang, Hongru Wang, Menglu Xu +1 more

Sepsis-induced acute kidney injury (AKI) continues to be associated with poor outcomes in critical care patients. Previous research has revealed that tetrahydrocurcumin (THC) exerts renoprotective effects in multiple nephritic disorders by modulating inflammation and oxidative stress. However, the effects of THC on sepsis-induced AKI and the underlying mechanisms remain unclear. In this study, a mouse model of sep…

Renal Failure Europe PMC

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Research Article 2021CC BYFree full text

Cannabidiol Induces Autophagy to Protects Neural Cells From Mitochondrial Dysfunction by Upregulating SIRT1 to Inhibits NF-κB and NOTCH Pathways.

Shaolei Kang, Jinglin Li, Zhihui Yao, Jiaxin Liu

The protective effect of Cannabidiol on Parkinson's disease (PD) has been found in recent study. However, the specific mechanism of the protective effect of Cannabidiol on PD nerve damage require further exploration. This study aims to investigate effect of Cannabidiol on MMP-induced Neural Cells (SH-SY5Y) mitochondrial dysfunction. MMP+ and Cannabidiol were used to treat SH-SY5Y cells, the cells viability was mea…

Frontiers in Cellular Neuroscience Europe PMC

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SIRT1 retention in elongating spermatids interferes with histone displacement by counteracting MOF-dependent H4K16 acetylation.

Exercise ameliorates stanozolol and cannabis co-abuse testicular damage in rats evidenced by biochemical and histological regulation of SIRT1 and STS.

Tetrahydrocurcumin protects against sepsis-induced acute kidney injury via the SIRT1 pathway.

Cannabidiol Induces Autophagy to Protects Neural Cells From Mitochondrial Dysfunction by Upregulating SIRT1 to Inhibits NF-κB and NOTCH Pathways.